Peripheral T-cell lymphoma with a T follicular-helper phenotype : A different entity? Results of the Spanish Real-T study
© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd..
Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7-73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
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| Enthalten in: |
British journal of haematology - 203(2023), 2 vom: 30. Okt., Seite 182-193 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martín García-Sancho, Alejandro [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 05.10.2023 Date Revised 06.10.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/bjh.18941 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358881579 |
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| 100 | 1 | |a Martín García-Sancho, Alejandro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Peripheral T-cell lymphoma with a T follicular-helper phenotype |b A different entity? Results of the Spanish Real-T study |
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| 520 | |a © 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. | ||
| 520 | |a Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7-73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a T-follicular helper cells | |
| 650 | 4 | |a nodal peripheral T-cell lymphoma with a T-follicular helper phenotype | |
| 650 | 4 | |a peripheral T-cell lymphoma | |
| 700 | 1 | |a Rodríguez-Pinilla, Socorro M |e verfasserin |4 aut | |
| 700 | 1 | |a Domingo-Domenech, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Climent, Fina |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Garcia, Joaquín |e verfasserin |4 aut | |
| 700 | 1 | |a López Jiménez, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a García-Cosío Piqueras, Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Castellvi, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a González, Ana Julia |e verfasserin |4 aut | |
| 700 | 1 | |a González de Villambrosia, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez Codina, José |e verfasserin |4 aut | |
| 700 | 1 | |a Navarro, Belén |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez, Guillermo |e verfasserin |4 aut | |
| 700 | 1 | |a Borrero, Juan José |e verfasserin |4 aut | |
| 700 | 1 | |a Fraga, Máximo |e verfasserin |4 aut | |
| 700 | 1 | |a Naves, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Baeza, Lourdes |e verfasserin |4 aut | |
| 700 | 1 | |a Córdoba, Raúl |e verfasserin |4 aut | |
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