Details der Publikation - Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

Copyright © 2024 Korean Society for Sexual Medicine and Andrology..

PURPOSE: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.

MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).

RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.

CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.

Medienart:	E-Artikel

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	Zur Gesamtaufnahme - volume:42
Enthalten in:	The world journal of men's health - 42(2024), 1 vom: 02. Jan., Seite 92-132

Sprache:	Englisch

Beteiligte Personen:	Cannarella, Rossella [VerfasserIn] Shah, Rupin [VerfasserIn] Hamoda, Taha Abo-Almagd Abdel-Meguid [VerfasserIn] Boitrelle, Florence [VerfasserIn] Saleh, Ramadan [VerfasserIn] Gul, Murat [VerfasserIn] Rambhatla, Amarnath [VerfasserIn] Kavoussi, Parviz [VerfasserIn] Toprak, Tuncay [VerfasserIn] Harraz, Ahmed M [VerfasserIn] Ko, Edmund [VerfasserIn] Çeker, Gökhan [VerfasserIn] Durairajanayagam, Damayanthi [VerfasserIn] Alkahidi, Noora [VerfasserIn] Kuroda, Shinnosuke [VerfasserIn] Crafa, Andrea [VerfasserIn] Henkel, Ralf [VerfasserIn] Salvio, Gianmaria [VerfasserIn] Hazir, Berk [VerfasserIn] Darbandi, Mahsa [VerfasserIn] Bendayan, Marion [VerfasserIn] Darbandi, Sara [VerfasserIn] Falcone, Marco [VerfasserIn] Garrido, Nicolas [VerfasserIn] Kosgi, Raghavender [VerfasserIn] Sawaid Kaiyal, Raneen [VerfasserIn] Karna, Keshab [VerfasserIn] Phuoc, Nguyen Ho Vinh [VerfasserIn] Birowo, Ponco [VerfasserIn] Colpi, Giovanni M [VerfasserIn] de la Rosette, Jean [VerfasserIn] Pinggera, Germar-Michael [VerfasserIn] Nguyen, Quang [VerfasserIn] Zini, Armand [VerfasserIn] Zohdy, Wael [VerfasserIn] Singh, Rajender [VerfasserIn] Saini, Pallavi [VerfasserIn] Glina, Sidney [VerfasserIn] Lin, Haocheng [VerfasserIn] Mostafa, Taymour [VerfasserIn] Rojas-Cruz, Cesar [VerfasserIn] Arafa, Mohamed [VerfasserIn] Calogero, Aldo E [VerfasserIn] Dimitriadis, Fotios [VerfasserIn] Kothari, Priyank [VerfasserIn] Karthikeyan, Vilvapathy Senguttuvan [VerfasserIn] Okada, Keisuke [VerfasserIn] Chiba, Koji [VerfasserIn] Kadıoglu, Ates [VerfasserIn] Altay, Baris [VerfasserIn] Turunc, Tahsin [VerfasserIn] Zilaitiene, Birute [VerfasserIn] Gokalp, Fatih [VerfasserIn] Adamyan, Aram [VerfasserIn] Katz, Darren [VerfasserIn] Chung, Eric [VerfasserIn] Mierzwa, Tiago Cesar [VerfasserIn] Zylbersztejn, Daniel Suslik [VerfasserIn] Paul, Gustavo Marquesine [VerfasserIn] Sofikitis, Nikolaos [VerfasserIn] Sokolakis, Ioannis [VerfasserIn] Malhotra, Vineet [VerfasserIn] Brodjonegoro, Sakti Ronggowardhana [VerfasserIn] Adriansjah, Ricky [VerfasserIn] Tsujimura, Akira [VerfasserIn] Amano, Toshiyasu [VerfasserIn] Balercia, Giancarlo [VerfasserIn] Ziouziou, Imad [VerfasserIn] Deswanto, Isaac Ardianson [VerfasserIn] Martinez, Marlon [VerfasserIn] Park, Hyun Jun [VerfasserIn] Bakırcıoglu, Mustafa Emre [VerfasserIn] Ceyhan, Erman [VerfasserIn] Aydos, Kaan [VerfasserIn] Ramsay, Jonathan [VerfasserIn] Minhas, Suks [VerfasserIn] Al Hashimi, Manaf [VerfasserIn] Ghayda, Ramy Abou [VerfasserIn] Tadros, Nicholas [VerfasserIn] Sindhwani, Puneet [VerfasserIn] Ho, Christopher C K [VerfasserIn] Rachman, Rinaldo Indra [VerfasserIn] Rodriguez Pena, Marcelo [VerfasserIn] Motawi, Ahmad [VerfasserIn] Ponnusamy, Arun Karthik [VerfasserIn] Dipankar, Satish [VerfasserIn] Amir, Azwar [VerfasserIn] Binsaleh, Saleh [VerfasserIn] Serefoglu, Ege Can [VerfasserIn] Banthia, Ravi [VerfasserIn] Khalafalla, Kareim [VerfasserIn] Basukarno, Ari [VerfasserIn] Bac, Nguyen Hoai [VerfasserIn] Singla, Karun [VerfasserIn] Ambar, Rafael F [VerfasserIn] Makarounis, Konstantinos [VerfasserIn] Priyadarshi, Shivam [VerfasserIn] Duarsa, Gede Wirya Kusuma [VerfasserIn] Atmoko, Widi [VerfasserIn] Jindal, Sunil [VerfasserIn] Global Andrology Forum [VerfasserIn] et al [Sonstige Person]

Links:	Volltext

Themen:	Controlled before-after studies Infertility, male Journal Article Meta-analysis Varicocele

Anmerkungen:	Date Revised 13.01.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE

doi:	10.5534/wjmh.230034

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	NLM358835763

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245	1	0	\|a Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
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520			\|a Copyright © 2024 Korean Society for Sexual Medicine and Andrology.
520			\|a PURPOSE: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles
520			\|a MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies)
520			\|a RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864
520			\|a CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele
650		4	\|a Journal Article
650		4	\|a Controlled before-after studies
650		4	\|a Infertility, male
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650		4	\|a Varicocele
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Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

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