The importance of microvascular inflammation in ageing and age-related diseases : a position paper from the ESH working group on small arteries, section of microvascular inflammation
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc..
Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and age-related disease. Microvascular dysfunction, if not targeted, leads to a steady derangement of the phenotype, which cumulates comorbidities and eventually results in a nonrescuable, very high-cardiovascular risk. Along the broad spectrum of pathologies, both shared and distinct molecular pathways and pathophysiological alteration are involved in the disruption of microvascular homeostasis, all pointing to microvascular inflammation as the putative primary culprit. This position paper explores the presence and the detrimental contribution of microvascular inflammation across the whole spectrum of chronic age-related diseases, which characterise the 21st-century healthcare landscape. The manuscript aims to strongly affirm the centrality of microvascular inflammation by recapitulating the current evidence and providing a clear synoptic view of the whole cardiometabolic derangement. Indeed, there is an urgent need for further mechanistic exploration to identify clear, very early or disease-specific molecular targets to provide an effective therapeutic strategy against the otherwise unstoppable rising prevalence of age-related diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
|---|---|
| Enthalten in: |
Journal of hypertension - 41(2023), 10 vom: 01. Okt., Seite 1521-1543 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 31.08.2023 Date Revised 08.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1097/HJH.0000000000003503 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM35883449X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM35883449X | ||
| 003 | DE-627 | ||
| 005 | 20231226075605.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/HJH.0000000000003503 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1196.xml |
| 035 | |a (DE-627)NLM35883449X | ||
| 035 | |a (NLM)37382158 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mengozzi, Alessandro |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The importance of microvascular inflammation in ageing and age-related diseases |b a position paper from the ESH working group on small arteries, section of microvascular inflammation |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.08.2023 | ||
| 500 | |a Date Revised 08.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. | ||
| 520 | |a Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and age-related disease. Microvascular dysfunction, if not targeted, leads to a steady derangement of the phenotype, which cumulates comorbidities and eventually results in a nonrescuable, very high-cardiovascular risk. Along the broad spectrum of pathologies, both shared and distinct molecular pathways and pathophysiological alteration are involved in the disruption of microvascular homeostasis, all pointing to microvascular inflammation as the putative primary culprit. This position paper explores the presence and the detrimental contribution of microvascular inflammation across the whole spectrum of chronic age-related diseases, which characterise the 21st-century healthcare landscape. The manuscript aims to strongly affirm the centrality of microvascular inflammation by recapitulating the current evidence and providing a clear synoptic view of the whole cardiometabolic derangement. Indeed, there is an urgent need for further mechanistic exploration to identify clear, very early or disease-specific molecular targets to provide an effective therapeutic strategy against the otherwise unstoppable rising prevalence of age-related diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a de Ciuceis, Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a Dell'oro, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Georgiopoulos, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Lazaridis, Antonios |e verfasserin |4 aut | |
| 700 | 1 | |a Nosalski, Ryszard |e verfasserin |4 aut | |
| 700 | 1 | |a Pavlidis, George |e verfasserin |4 aut | |
| 700 | 1 | |a Tual-Chalot, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Agabiti-Rosei, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Anyfanti, Panagiota |e verfasserin |4 aut | |
| 700 | 1 | |a Camargo, Livia L |e verfasserin |4 aut | |
| 700 | 1 | |a Dąbrowska, Edyta |e verfasserin |4 aut | |
| 700 | 1 | |a Quarti-Trevano, Fosca |e verfasserin |4 aut | |
| 700 | 1 | |a Hellmann, Marcin |e verfasserin |4 aut | |
| 700 | 1 | |a Masi, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Mavraganis, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Montezano, Augusto C |e verfasserin |4 aut | |
| 700 | 1 | |a Rios, Francesco J |e verfasserin |4 aut | |
| 700 | 1 | |a Winklewski, Pawel J |e verfasserin |4 aut | |
| 700 | 1 | |a Wolf, Jacek |e verfasserin |4 aut | |
| 700 | 1 | |a Costantino, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Gkaliagkousi, Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Grassi, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Guzik, Tomasz J |e verfasserin |4 aut | |
| 700 | 1 | |a Ikonomidis, Ignatios |e verfasserin |4 aut | |
| 700 | 1 | |a Narkiewicz, Krzysztof |e verfasserin |4 aut | |
| 700 | 1 | |a Paneni, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Rizzoni, Damiano |e verfasserin |4 aut | |
| 700 | 1 | |a Stamatelopoulos, Kimon |e verfasserin |4 aut | |
| 700 | 1 | |a Stellos, Konstantinos |e verfasserin |4 aut | |
| 700 | 1 | |a Taddei, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Touyz, Rhian M |e verfasserin |4 aut | |
| 700 | 1 | |a Triantafyllou, Areti |e verfasserin |4 aut | |
| 700 | 1 | |a Virdis, Agostino |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of hypertension |d 1987 |g 41(2023), 10 vom: 01. Okt., Seite 1521-1543 |w (DE-627)NLM01293562X |x 1473-5598 |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:2023 |g number:10 |g day:01 |g month:10 |g pages:1521-1543 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/HJH.0000000000003503 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 41 |j 2023 |e 10 |b 01 |c 10 |h 1521-1543 | ||