PPARα is involved in high-fat diet-induced risk avoidance impairment via the regulation of hippocampal BDNF
Risk avoidance behaviors are essential for survival. "Uncontrollable" risk-taking behaviors in animals or humans may have severe adverse consequences. In humans, a large proportion of psychiatric disorders are accompanied by impairments in risk avoidance. Obesity is associated with psychiatric disorders. Peroxisome proliferator-activated receptor α (PPARα) takes part in regulating lipid metabolism and neuronal function. Here, we investigated the effect of high-fat diet (HFD)-induced obesity on risk avoidance and the role of PPARα in this behavior. Male PPARα-null (KO) mice and wild-type (WT) mice were assigned to four different groups: WT-CON and KO-CON (normal diet); WT-HFD and KO-HFD (high fat diet). The HFD began at week 6 and was continued until sampling. A series of behavioral tests were performed at week 11. We found that WT but not KO mice fed with a HFD exhibited weight gain and risk avoidance impairment, compared with the mice fed with a normal diet. The staining of c-Fos revealed that the hippocampus was the main brain region involved in risk avoidance behavior. Moreover, biochemical analysis suggested that the decreased levels of the brain-derived neurotrophic factor (BDNF) in the hippocampus might contribute to risk avoidance impairment induced by a HFD. These results indicated that PPARα is involved in HFD-induced risk avoidance impairment via the regulation of hippocampal BDNF.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Food & function - 14(2023), 14 vom: 17. Juli, Seite 6541-6553 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Xin-Yi [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 19.07.2023 Date Revised 19.07.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d3fo01636f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358830133 |
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| 520 | |a Risk avoidance behaviors are essential for survival. "Uncontrollable" risk-taking behaviors in animals or humans may have severe adverse consequences. In humans, a large proportion of psychiatric disorders are accompanied by impairments in risk avoidance. Obesity is associated with psychiatric disorders. Peroxisome proliferator-activated receptor α (PPARα) takes part in regulating lipid metabolism and neuronal function. Here, we investigated the effect of high-fat diet (HFD)-induced obesity on risk avoidance and the role of PPARα in this behavior. Male PPARα-null (KO) mice and wild-type (WT) mice were assigned to four different groups: WT-CON and KO-CON (normal diet); WT-HFD and KO-HFD (high fat diet). The HFD began at week 6 and was continued until sampling. A series of behavioral tests were performed at week 11. We found that WT but not KO mice fed with a HFD exhibited weight gain and risk avoidance impairment, compared with the mice fed with a normal diet. The staining of c-Fos revealed that the hippocampus was the main brain region involved in risk avoidance behavior. Moreover, biochemical analysis suggested that the decreased levels of the brain-derived neurotrophic factor (BDNF) in the hippocampus might contribute to risk avoidance impairment induced by a HFD. These results indicated that PPARα is involved in HFD-induced risk avoidance impairment via the regulation of hippocampal BDNF | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a PPAR alpha |2 NLM | |
| 650 | 7 | |a Brain-Derived Neurotrophic Factor |2 NLM | |
| 700 | 1 | |a Luo, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Xiao-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Lu-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xiao-Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Lin-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Yi-Bei |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Ying-Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Fei-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Le |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Li-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ai-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiao-Qin |e verfasserin |4 aut | |
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