Performance of the beta-glucan test for the diagnosis of invasive fusariosis and scedosporiosis : a meta-analysis
© The Author(s) 2023. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology..
The (1→3)-β-D-glucan (BDG) is a component of the fungal cell wall that can be detected in serum and used as an adjunctive tool for the diagnosis of invasive mold infections (IMI) in patients with hematologic cancer or other immunosuppressive conditions. However, its use is limited by modest sensitivity/specificity, inability to differentiate between fungal pathogens, and lack of detection of mucormycosis. Data about BDG performance for other relevant IMI, such as invasive fusariosis (IF) and invasive scedosporiosis/lomentosporiosis (IS) are scarce. The objective of this study was to assess the sensitivity of BDG for the diagnosis of IF and IS through systematic literature review and meta-analysis. Immunosuppressed patients diagnosed with proven or probable IF and IS, with interpretable BDG data were eligible. A total of 73 IF and 27 IS cases were included. The sensitivity of BDG for IF and IS diagnosis was 76.7% and 81.5%, respectively. In comparison, the sensitivity of serum galactomannan for IF was 27%. Importantly, BDG positivity preceded the diagnosis by conventional methods (culture or histopathology) in 73% and 94% of IF and IS cases, respectively. Specificity was not assessed because of lacking data. In conclusion, BDG testing may be useful in patients with suspected IF or IS. Combining BDG and galactomannan testing may also help differentiating between the different types of IMI.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
|---|---|
| Enthalten in: |
Medical mycology - 61(2023), 7 vom: 06. Juli |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lamoth, Frederic [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute leukemia |
|---|
| Anmerkungen: |
Date Completed 27.07.2023 Date Revised 09.08.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/mmy/myad061 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM358824729 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM358824729 | ||
| 003 | DE-627 | ||
| 005 | 20231226075552.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/mmy/myad061 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1196.xml |
| 035 | |a (DE-627)NLM358824729 | ||
| 035 | |a (NLM)37381179 | ||
| 035 | |a (PII)myad061 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lamoth, Frederic |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Performance of the beta-glucan test for the diagnosis of invasive fusariosis and scedosporiosis |b a meta-analysis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.07.2023 | ||
| 500 | |a Date Revised 09.08.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. | ||
| 520 | |a The (1→3)-β-D-glucan (BDG) is a component of the fungal cell wall that can be detected in serum and used as an adjunctive tool for the diagnosis of invasive mold infections (IMI) in patients with hematologic cancer or other immunosuppressive conditions. However, its use is limited by modest sensitivity/specificity, inability to differentiate between fungal pathogens, and lack of detection of mucormycosis. Data about BDG performance for other relevant IMI, such as invasive fusariosis (IF) and invasive scedosporiosis/lomentosporiosis (IS) are scarce. The objective of this study was to assess the sensitivity of BDG for the diagnosis of IF and IS through systematic literature review and meta-analysis. Immunosuppressed patients diagnosed with proven or probable IF and IS, with interpretable BDG data were eligible. A total of 73 IF and 27 IS cases were included. The sensitivity of BDG for IF and IS diagnosis was 76.7% and 81.5%, respectively. In comparison, the sensitivity of serum galactomannan for IF was 27%. Importantly, BDG positivity preceded the diagnosis by conventional methods (culture or histopathology) in 73% and 94% of IF and IS cases, respectively. Specificity was not assessed because of lacking data. In conclusion, BDG testing may be useful in patients with suspected IF or IS. Combining BDG and galactomannan testing may also help differentiating between the different types of IMI | ||
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Fusarium | |
| 650 | 4 | |a Lomentospora prolificans | |
| 650 | 4 | |a Scedosporium apiospermum | |
| 650 | 4 | |a acute leukemia | |
| 650 | 4 | |a beta-D-glucan | |
| 650 | 4 | |a invasive fungal infections | |
| 650 | 4 | |a transplant recipients | |
| 650 | 7 | |a beta-Glucans |2 NLM | |
| 700 | 1 | |a Nucci, Marcio |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez-Cruz, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Azoulay, Elie |e verfasserin |4 aut | |
| 700 | 1 | |a Lanternier, Fanny |e verfasserin |4 aut | |
| 700 | 1 | |a Bremerich, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Einsele, Hermann |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Lehrnbecher, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Mercier, Toine |e verfasserin |4 aut | |
| 700 | 1 | |a Porto, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Verweij, Paul E |e verfasserin |4 aut | |
| 700 | 1 | |a White, Lewis |e verfasserin |4 aut | |
| 700 | 1 | |a Maertens, Johan |e verfasserin |4 aut | |
| 700 | 1 | |a Alanio, Alexandre |e verfasserin |4 aut | |
| 700 | 0 | |a 9th European Conference on Infections in Leukemia (ECIL-9) |e verfasserin |4 aut | |
| 700 | 1 | |a Aerts, Robina |e investigator |4 oth | |
| 700 | 1 | |a Akova, Murat |e investigator |4 oth | |
| 700 | 1 | |a Alanio, Alexandre |e investigator |4 oth | |
| 700 | 1 | |a Averbuch, Diana |e investigator |4 oth | |
| 700 | 1 | |a Blennow, Ola |e investigator |4 oth | |
| 700 | 1 | |a Bretagne, Stéphane |e investigator |4 oth | |
| 700 | 1 | |a Busca, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Calandra, Thierry |e investigator |4 oth | |
| 700 | 1 | |a Cesaro, Simone |e investigator |4 oth | |
| 700 | 1 | |a Cordonnier, Catherine |e investigator |4 oth | |
| 700 | 1 | |a De La Camara, Rafael |e investigator |4 oth | |
| 700 | 1 | |a Garcia-Vidal, Caroline |e investigator |4 oth | |
| 700 | 1 | |a Gil, Lidia |e investigator |4 oth | |
| 700 | 1 | |a Groll, Andreas |e investigator |4 oth | |
| 700 | 1 | |a Herbrecht, Raoul |e investigator |4 oth | |
| 700 | 1 | |a Hirsch, Hans |e investigator |4 oth | |
| 700 | 1 | |a Hubacek, Peter |e investigator |4 oth | |
| 700 | 1 | |a Indolfi, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Kassa, Csaba |e investigator |4 oth | |
| 700 | 1 | |a Lagrou, Katrien |e investigator |4 oth | |
| 700 | 1 | |a Lamoth, Frederic |e investigator |4 oth | |
| 700 | 1 | |a Lehrnbecher, Thomas |e investigator |4 oth | |
| 700 | 1 | |a Ljungman, Per |e investigator |4 oth | |
| 700 | 1 | |a Maertens, Johan |e investigator |4 oth | |
| 700 | 1 | |a Mallet, Vincent |e investigator |4 oth | |
| 700 | 1 | |a Martino, Rodrigo |e investigator |4 oth | |
| 700 | 1 | |a Mehra, Varun |e investigator |4 oth | |
| 700 | 1 | |a Mercier, Toine |e investigator |4 oth | |
| 700 | 1 | |a Mikulska, Malgorzata |e investigator |4 oth | |
| 700 | 1 | |a Nucci, Marcio |e investigator |4 oth | |
| 700 | 1 | |a Pagano, Livio |e investigator |4 oth | |
| 700 | 1 | |a Perruccio, Katia |e investigator |4 oth | |
| 700 | 1 | |a PiÑana, Jose Luis |e investigator |4 oth | |
| 700 | 1 | |a Porto, Luciana |e investigator |4 oth | |
| 700 | 1 | |a Robin, Christine |e investigator |4 oth | |
| 700 | 1 | |a Roilides, Emmanuel |e investigator |4 oth | |
| 700 | 1 | |a Slavin, Monica |e investigator |4 oth | |
| 700 | 1 | |a Styczynski, Jan |e investigator |4 oth | |
| 700 | 1 | |a Tverdek, Frank |e investigator |4 oth | |
| 700 | 1 | |a Verweij, Paul |e investigator |4 oth | |
| 700 | 1 | |a Vissing, Nadja Hawwa |e investigator |4 oth | |
| 700 | 1 | |a White, Lewis |e investigator |4 oth | |
| 700 | 1 | |a Xhaard, Alienor |e investigator |4 oth | |
| 700 | 1 | |a Spychala, Olga Zajac |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Medical mycology |d 1997 |g 61(2023), 7 vom: 06. Juli |w (DE-627)NLM097151785 |x 1460-2709 |7 nnns |
| 773 | 1 | 8 | |g volume:61 |g year:2023 |g number:7 |g day:06 |g month:07 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/mmy/myad061 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 61 |j 2023 |e 7 |b 06 |c 07 | ||