Comparison of diffusion weighted imaging b0 with T2*-weighted gradient echo or susceptibility weighted imaging for intracranial hemorrhage detection after reperfusion therapy for ischemic stroke
© 2023. The Author(s)..
PURPOSE: Diffusion-weighted imaging (DWI) b0 may be able to substitute T2*-weighted gradient echo (GRE) or susceptibility-weighted imaging (SWI) in case of comparable detection of intracranial hemorrhage (ICH), thereby reducing MRI examination time. We evaluated the diagnostic accuracy of DWI b0 compared to T2*GRE or SWI for detection of ICH after reperfusion therapy for ischemic stroke.
METHODS: We pooled 300 follow-up MRI scans acquired within 1 week after reperfusion therapy. Six neuroradiologists each rated DWI images (b0 and b1000; b0 as index test) of 100 patients and, after a minimum of 4 weeks, T2*GRE or SWI images (reference standard) paired with DWI images of the same patients. Readers assessed the presence of ICH (yes/no) and type of ICH according to the Heidelberg Bleeding Classification. We determined the sensitivity and specificity of DWI b0 for detection of any ICH, and the sensitivity for detection of hemorrhagic infarction (HI1 & HI2) and parenchymal hematoma (PH1 & PH2).
RESULTS: We analyzed 277 scans of ischemic stroke patients with complete image series and sufficient image quality (median age 65 years [interquartile range, 54-75], 158 [57%] men). For detection of any ICH on DWI b0, the sensitivity was 62% (95% CI: 50-76) and specificity 96% (95% CI: 93-99). The sensitivity of DWI b0 was 52% (95% CI: 28-68) for detection of hemorrhagic infarction and 84% (95% CI: 70-92) for parenchymal hematoma.
CONCLUSION: DWI b0 is inferior for detection of ICH compared to T2*GRE/SWI, especially for smaller and more subtle hemorrhages. Follow-up MRI protocols should include T2*GRE/SWI for detection of ICH after reperfusion therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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| Enthalten in: |
Neuroradiology - 65(2023), 11 vom: 28. Nov., Seite 1649-1655 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Luijten, Sven P R [VerfasserIn] |
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| Links: |
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| Themen: |
Intracranial hemorrhage |
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| Anmerkungen: |
Date Revised 14.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s00234-023-03180-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358821835 |
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| 100 | 1 | |a Luijten, Sven P R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of diffusion weighted imaging b0 with T2*-weighted gradient echo or susceptibility weighted imaging for intracranial hemorrhage detection after reperfusion therapy for ischemic stroke |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 14.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: Diffusion-weighted imaging (DWI) b0 may be able to substitute T2*-weighted gradient echo (GRE) or susceptibility-weighted imaging (SWI) in case of comparable detection of intracranial hemorrhage (ICH), thereby reducing MRI examination time. We evaluated the diagnostic accuracy of DWI b0 compared to T2*GRE or SWI for detection of ICH after reperfusion therapy for ischemic stroke | ||
| 520 | |a METHODS: We pooled 300 follow-up MRI scans acquired within 1 week after reperfusion therapy. Six neuroradiologists each rated DWI images (b0 and b1000; b0 as index test) of 100 patients and, after a minimum of 4 weeks, T2*GRE or SWI images (reference standard) paired with DWI images of the same patients. Readers assessed the presence of ICH (yes/no) and type of ICH according to the Heidelberg Bleeding Classification. We determined the sensitivity and specificity of DWI b0 for detection of any ICH, and the sensitivity for detection of hemorrhagic infarction (HI1 & HI2) and parenchymal hematoma (PH1 & PH2) | ||
| 520 | |a RESULTS: We analyzed 277 scans of ischemic stroke patients with complete image series and sufficient image quality (median age 65 years [interquartile range, 54-75], 158 [57%] men). For detection of any ICH on DWI b0, the sensitivity was 62% (95% CI: 50-76) and specificity 96% (95% CI: 93-99). The sensitivity of DWI b0 was 52% (95% CI: 28-68) for detection of hemorrhagic infarction and 84% (95% CI: 70-92) for parenchymal hematoma | ||
| 520 | |a CONCLUSION: DWI b0 is inferior for detection of ICH compared to T2*GRE/SWI, especially for smaller and more subtle hemorrhages. Follow-up MRI protocols should include T2*GRE/SWI for detection of ICH after reperfusion therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Intracranial hemorrhage | |
| 650 | 4 | |a Ischemic stroke | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Reperfusion | |
| 700 | 1 | |a van der Ende, Nadinda A M |e verfasserin |4 aut | |
| 700 | 1 | |a Cornelissen, Sandra A P |e verfasserin |4 aut | |
| 700 | 1 | |a Kluijtmans, Leo |e verfasserin |4 aut | |
| 700 | 1 | |a van Hattem, Antonius |e verfasserin |4 aut | |
| 700 | 1 | |a Lycklama A Nijeholt, Geert |e verfasserin |4 aut | |
| 700 | 1 | |a Postma, Alida A |e verfasserin |4 aut | |
| 700 | 1 | |a Bokkers, Reinoud P H |e verfasserin |4 aut | |
| 700 | 1 | |a Thomassen, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Waje-Andreassen, Ulrike |e verfasserin |4 aut | |
| 700 | 1 | |a Logallo, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Bracard, Serge |e verfasserin |4 aut | |
| 700 | 1 | |a Gory, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Roozenbeek, Bob |e verfasserin |4 aut | |
| 700 | 1 | |a Dippel, Diederik W J |e verfasserin |4 aut | |
| 700 | 1 | |a van der Lugt, Aad |e verfasserin |4 aut | |
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