Chiral Discrimination of Nitrile Compounds Using a 19F-Labeled Palladium Probe
This study presents a 19F-labeled cyclopalladium probe for the rapid discrimination of chiral nitriles in pharmaceuticals, natural products, and agrochemicals. The probe binds reversibly to chiral nitriles, generating distinct 19F nuclear magnetic resonance signals for each enantiomer and enabling quick determination of enantiocomposition. The method allows for simultaneous detection of seven pairs of enantiomeric nitriles and application in assessing the enantiomeric excess of an asymmetric C-H cyanation reaction.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Organic letters - 25(2023), 26 vom: 07. Juli, Seite 4819-4824 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gu, Guangxing [VerfasserIn] |
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| Anmerkungen: |
Date Completed 09.07.2023 Date Revised 18.07.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.3c01525 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358798329 |
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| 245 | 1 | 0 | |a Chiral Discrimination of Nitrile Compounds Using a 19F-Labeled Palladium Probe |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a This study presents a 19F-labeled cyclopalladium probe for the rapid discrimination of chiral nitriles in pharmaceuticals, natural products, and agrochemicals. The probe binds reversibly to chiral nitriles, generating distinct 19F nuclear magnetic resonance signals for each enantiomer and enabling quick determination of enantiocomposition. The method allows for simultaneous detection of seven pairs of enantiomeric nitriles and application in assessing the enantiomeric excess of an asymmetric C-H cyanation reaction | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Yue, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chenyang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ya |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yanchuan |e verfasserin |4 aut | |
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