Toward a Systematic Assessment of Sex Differences in Cystic Fibrosis
(1) Background: Cystic fibrosis (CF) is a disease with well-documented clinical differences between female and male patients. However, this gender gap is very poorly studied at the molecular level. (2) Methods: Expression differences in whole blood transcriptomics between female and male CF patients are analyzed in order to determine the pathways related to sex-biased genes and assess their potential influence on sex-specific effects in CF patients. (3) Results: We identify sex-biased genes in female and male CF patients and provide explanations for some sex-specific differences at the molecular level. (4) Conclusion: Genes in key pathways associated with CF are differentially expressed between sexes, and thus may account for the gender gap in morbidity and mortality in CF.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Journal of personalized medicine - 13(2023), 6 vom: 31. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gärtner, Christiane [VerfasserIn] |
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| Links: |
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| Themen: |
CAMP signaling pathway |
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| Anmerkungen: |
Date Revised 01.07.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jpm13060924 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM358752256 |
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| 520 | |a (1) Background: Cystic fibrosis (CF) is a disease with well-documented clinical differences between female and male patients. However, this gender gap is very poorly studied at the molecular level. (2) Methods: Expression differences in whole blood transcriptomics between female and male CF patients are analyzed in order to determine the pathways related to sex-biased genes and assess their potential influence on sex-specific effects in CF patients. (3) Results: We identify sex-biased genes in female and male CF patients and provide explanations for some sex-specific differences at the molecular level. (4) Conclusion: Genes in key pathways associated with CF are differentially expressed between sexes, and thus may account for the gender gap in morbidity and mortality in CF | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Fallmann, Jörg |e verfasserin |4 aut | |
| 700 | 1 | |a Stadler, Peter F |e verfasserin |4 aut | |
| 700 | 1 | |a Kaiser, Thorsten |e verfasserin |4 aut | |
| 700 | 1 | |a Berkemer, Sarah J |e verfasserin |4 aut | |
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