A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection
AIM: Concerns have been raised about possible neuropsychiatric sequelae of COVID-19. The objective of this study was to examine the plausibility of long-term mental health consequences of COVID-19 by assessing a sample of children after the resolution of the acute SARS-CoV-2 infection.
METHOD: As part of a systematic follow-up assessment of pediatric patients with COVID-19 conducted at two university children's hospitals, 50 children (56% males) aged 8 to 17 years (median 11.5), 26% with previous multisystem inflammatory syndrome in children (MIS-C), without a prior history of neuropsychiatric disorders, received a battery of clinical neuropsychiatric and neuropsychological rating scales that included the Pediatric Migraine Disability Assessment (PedMIDAS), Sleep Disturbance Scale for Children (SDSC), Multidimensional Anxiety Scale for Children (MASC-2), Child Depression Inventory (CDI-2), Child Behavior Checklist (CBCL), and the NEPSY II (Neuropsychological Assessment, Second Edition). The assessments were conducted between 1 and 18 months (median 8 months) after the acute infection.
RESULTS: The CBCL internalizing symptoms score was in the clinical range for 40% of the participants (vs. a population expected rate of about 10%, p < 0.001). A sleep disturbance was detected in 28%, clinically significant anxiety in 48%, and depressive symptoms in 16%. The NEPSY II scores showed impairment in attention and other executive functions in 52%, and memory deficits in 40% of the children.
CONCLUSIONS: These data from direct assessment of a sample of children who had SARS-CoV-2 infection show higher than expected rates of neuropsychiatric symptoms, thus supporting the possibility that COVID-19 may have mental health sequelae long after the resolution of the acute infection.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
---|---|
Enthalten in: |
Journal of clinical medicine - 12(2023), 12 vom: 08. Juni |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Scarselli, Veronica [VerfasserIn] |
---|
Links: |
---|
Themen: |
Adolescents |
---|
Anmerkungen: |
Date Revised 01.07.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3390/jcm12123917 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM358749239 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM358749239 | ||
003 | DE-627 | ||
005 | 20231226075413.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/jcm12123917 |2 doi | |
028 | 5 | 2 | |a pubmed24n1195.xml |
035 | |a (DE-627)NLM358749239 | ||
035 | |a (NLM)37373611 | ||
035 | |a (PII)3917 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Scarselli, Veronica |e verfasserin |4 aut | |
245 | 1 | 2 | |a A Neuropsychiatric Assessment of Children with Previous SARS-CoV-2 Infection |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 01.07.2023 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a AIM: Concerns have been raised about possible neuropsychiatric sequelae of COVID-19. The objective of this study was to examine the plausibility of long-term mental health consequences of COVID-19 by assessing a sample of children after the resolution of the acute SARS-CoV-2 infection | ||
520 | |a METHOD: As part of a systematic follow-up assessment of pediatric patients with COVID-19 conducted at two university children's hospitals, 50 children (56% males) aged 8 to 17 years (median 11.5), 26% with previous multisystem inflammatory syndrome in children (MIS-C), without a prior history of neuropsychiatric disorders, received a battery of clinical neuropsychiatric and neuropsychological rating scales that included the Pediatric Migraine Disability Assessment (PedMIDAS), Sleep Disturbance Scale for Children (SDSC), Multidimensional Anxiety Scale for Children (MASC-2), Child Depression Inventory (CDI-2), Child Behavior Checklist (CBCL), and the NEPSY II (Neuropsychological Assessment, Second Edition). The assessments were conducted between 1 and 18 months (median 8 months) after the acute infection | ||
520 | |a RESULTS: The CBCL internalizing symptoms score was in the clinical range for 40% of the participants (vs. a population expected rate of about 10%, p < 0.001). A sleep disturbance was detected in 28%, clinically significant anxiety in 48%, and depressive symptoms in 16%. The NEPSY II scores showed impairment in attention and other executive functions in 52%, and memory deficits in 40% of the children | ||
520 | |a CONCLUSIONS: These data from direct assessment of a sample of children who had SARS-CoV-2 infection show higher than expected rates of neuropsychiatric symptoms, thus supporting the possibility that COVID-19 may have mental health sequelae long after the resolution of the acute infection | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a adolescents | |
650 | 4 | |a children | |
650 | 4 | |a long-COVID | |
700 | 1 | |a Calderoni, Dario |e verfasserin |4 aut | |
700 | 1 | |a Terrinoni, Arianna |e verfasserin |4 aut | |
700 | 1 | |a Davico, Chiara |e verfasserin |4 aut | |
700 | 1 | |a Pruccoli, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Denina, Marco |e verfasserin |4 aut | |
700 | 1 | |a Carducci, Chiara |e verfasserin |4 aut | |
700 | 1 | |a Smarrazzo, Andrea |e verfasserin |4 aut | |
700 | 1 | |a Martucci, Melania |e verfasserin |4 aut | |
700 | 1 | |a Presicce, Mariaelena |e verfasserin |4 aut | |
700 | 1 | |a Marcotulli, Daniele |e verfasserin |4 aut | |
700 | 1 | |a Arletti, Luca |e verfasserin |4 aut | |
700 | 1 | |a Ferrara, Mauro |e verfasserin |4 aut | |
700 | 1 | |a Garazzino, Silvia |e verfasserin |4 aut | |
700 | 1 | |a Mariani, Rosanna |e verfasserin |4 aut | |
700 | 1 | |a Campana, Andrea |e verfasserin |4 aut | |
700 | 1 | |a Vitiello, Benedetto |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of clinical medicine |d 2012 |g 12(2023), 12 vom: 08. Juni |w (DE-627)NLM230666310 |x 2077-0383 |7 nnns |
773 | 1 | 8 | |g volume:12 |g year:2023 |g number:12 |g day:08 |g month:06 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/jcm12123917 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 12 |j 2023 |e 12 |b 08 |c 06 |