Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow's Milk Protein Allergy
Cow's milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or "dysbiosis". Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics' efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
International journal of molecular sciences - 24(2023), 12 vom: 06. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cela, Ludovica [VerfasserIn] |
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| Links: |
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| Themen: |
Children |
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| Anmerkungen: |
Date Completed 29.06.2023 Date Revised 01.07.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms24129781 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358742439 |
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| 520 | |a Cow's milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or "dysbiosis". Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics' efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms | ||
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| 700 | 1 | |a Gravina, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Pastore, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Semeraro, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Bringheli, Ivana |e verfasserin |4 aut | |
| 700 | 1 | |a Marchetti, Lavinia |e verfasserin |4 aut | |
| 700 | 1 | |a Morelli, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Cinicola, Bianca |e verfasserin |4 aut | |
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| 700 | 1 | |a Zicari, Anna Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Anania, Caterina |e verfasserin |4 aut | |
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