Intraoperative Molecular Positron Emission Tomography Imaging for Intraoperative Assessment of Radical Prostatectomy Specimens
© 2023 The Author(s)..
In this prospective two-center feasibility study, we evaluate the diagnostic value of intraoperative ex vivo specimenPET/CT imaging of radical prostatectomy (RP) and lymphadenectomy specimens. Ten patients with high-risk prostate cancer underwent clinical prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) preoperatively on the day of surgery. Six patients received 68Ga-PSMA-11 and four 18F-PSMA-1007. Radioactivity of the resected specimen was measured again using a novel specimenPET/CT device (AURA10; XEOS Medical, Gent, Belgium) developed for intraoperative margin assessment. All index lesions of staging multiparametric magnetic resonance imaging could be visualized. Overall, specimenPET/CT correlated well with conventional PET/CT regarding detection of suspicious tracer foci (Pearson coefficient 0.935). In addition, specimenPET/CT demonstrated all lymph node metastases detected on conventional PET/CT (n = 3), as well as three previously undetected lymph node metastases. Importantly, all positive or close (<1 mm) surgical margins could be visualized in agreement with histopathology. In conclusion, specimenPET/CT enables detection of PSMA-avid lesions and warrants further investigation to tailor RP, based on a good correlation with final pathology. Future trials will prospectively compare ex vivo specimenPET/CT with a frozen section analysis for the detection of positive surgical margins and assessment of biochemical recurrence-free survival.
Patient summary: In this report, we examined prostatectomy and lymphadenectomy specimens for suspicious positron emission tomography (PET) signals after preoperative tracer injection. It was found that in all cases, a good signal could be visualized, with a promising correlation of surface assessment compared with histopathology. We conclude that specimenPET imaging is feasible and may help improve oncological outcomes in the future.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
|---|---|
| Enthalten in: |
European urology open science - 54(2023) vom: 15. Aug., Seite 28-32 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Darr, Christopher [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Revised 01.07.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1016/j.euros.2023.05.017 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM358625564 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM358625564 | ||
| 003 | DE-627 | ||
| 005 | 20231226075139.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.euros.2023.05.017 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1195.xml |
| 035 | |a (DE-627)NLM358625564 | ||
| 035 | |a (NLM)37361199 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Darr, Christopher |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Intraoperative Molecular Positron Emission Tomography Imaging for Intraoperative Assessment of Radical Prostatectomy Specimens |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 01.07.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Author(s). | ||
| 520 | |a In this prospective two-center feasibility study, we evaluate the diagnostic value of intraoperative ex vivo specimenPET/CT imaging of radical prostatectomy (RP) and lymphadenectomy specimens. Ten patients with high-risk prostate cancer underwent clinical prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) preoperatively on the day of surgery. Six patients received 68Ga-PSMA-11 and four 18F-PSMA-1007. Radioactivity of the resected specimen was measured again using a novel specimenPET/CT device (AURA10; XEOS Medical, Gent, Belgium) developed for intraoperative margin assessment. All index lesions of staging multiparametric magnetic resonance imaging could be visualized. Overall, specimenPET/CT correlated well with conventional PET/CT regarding detection of suspicious tracer foci (Pearson coefficient 0.935). In addition, specimenPET/CT demonstrated all lymph node metastases detected on conventional PET/CT (n = 3), as well as three previously undetected lymph node metastases. Importantly, all positive or close (<1 mm) surgical margins could be visualized in agreement with histopathology. In conclusion, specimenPET/CT enables detection of PSMA-avid lesions and warrants further investigation to tailor RP, based on a good correlation with final pathology. Future trials will prospectively compare ex vivo specimenPET/CT with a frozen section analysis for the detection of positive surgical margins and assessment of biochemical recurrence-free survival | ||
| 520 | |a Patient summary: In this report, we examined prostatectomy and lymphadenectomy specimens for suspicious positron emission tomography (PET) signals after preoperative tracer injection. It was found that in all cases, a good signal could be visualized, with a promising correlation of surface assessment compared with histopathology. We conclude that specimenPET imaging is feasible and may help improve oncological outcomes in the future | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a Prostate-specific membrane antigen positron emission tomography/computed tomography | |
| 650 | 4 | |a Radical prostatectomy | |
| 650 | 4 | |a SpecimenPET/CT | |
| 700 | 1 | |a Costa, Pedro Fragoso |e verfasserin |4 aut | |
| 700 | 1 | |a Kahl, Theresa |e verfasserin |4 aut | |
| 700 | 1 | |a Moraitis, Alexandros |e verfasserin |4 aut | |
| 700 | 1 | |a Engel, Jenna |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Nader, Mulham |e verfasserin |4 aut | |
| 700 | 1 | |a Reis, Henning |e verfasserin |4 aut | |
| 700 | 1 | |a Köllermann, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Kesch, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Krafft, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Maurer, Tobias |e verfasserin |4 aut | |
| 700 | 1 | |a Köhler, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Klutmann, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Falkenbach, Fabian |e verfasserin |4 aut | |
| 700 | 1 | |a Kleesiek, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Fendler, Wolfgang P |e verfasserin |4 aut | |
| 700 | 1 | |a Hadaschik, Boris A |e verfasserin |4 aut | |
| 700 | 1 | |a Herrmann, Ken |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European urology open science |d 2020 |g 54(2023) vom: 15. Aug., Seite 28-32 |w (DE-627)NLM315704977 |x 2666-1683 |7 nnns |
| 773 | 1 | 8 | |g volume:54 |g year:2023 |g day:15 |g month:08 |g pages:28-32 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.euros.2023.05.017 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 54 |j 2023 |b 15 |c 08 |h 28-32 | ||