Epigenetics of Hypogonadotropic Hypogonadism : Molecular Mimicry between Severe Acute Respiratory Syndrome Coronavirus 2 and KISSR
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ )..
This study analyzed KISS1 and its receptor KISSR for peptide sharing with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was found that SARS-CoV-2 shares numerous minimal immune pentapeptide determinants with KISSR only. The peptide sharing has a high immunologic potential since almost all the common peptides are present in 101 SARS-CoV-2-derived immunoreactive epitopes. Data are in favor of configuring molecular mimicry as an epigenetic factor that can alter KISSR thus causing the hypogonadotropic hypogonadism syndrome with which altered KISSR associates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Global medical genetics - 10(2023), 2 vom: 21. Juni, Seite 129-132 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kanduc, Darja [VerfasserIn] |
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| Links: |
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| Themen: |
Autoimmunity: hypogonadotropic hypogonadism |
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| Anmerkungen: |
Date Revised 01.07.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1055/s-0043-1770767 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358613604 |
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| 245 | 1 | 0 | |a Epigenetics of Hypogonadotropic Hypogonadism |b Molecular Mimicry between Severe Acute Respiratory Syndrome Coronavirus 2 and KISSR |
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| 500 | |a Date Revised 01.07.2023 | ||
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). | ||
| 520 | |a This study analyzed KISS1 and its receptor KISSR for peptide sharing with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was found that SARS-CoV-2 shares numerous minimal immune pentapeptide determinants with KISSR only. The peptide sharing has a high immunologic potential since almost all the common peptides are present in 101 SARS-CoV-2-derived immunoreactive epitopes. Data are in favor of configuring molecular mimicry as an epigenetic factor that can alter KISSR thus causing the hypogonadotropic hypogonadism syndrome with which altered KISSR associates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a KISSR | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a autoimmunity: hypogonadotropic hypogonadism | |
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