Catheter-directed therapy for acute pulmonary embolism : results of a multicenter national registry
Copyright © 2023 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved..
INTRODUCTION AND OBJECTIVES: Catheter-directed therapy (CDT) for acute pulmonary embolism (PE) is an emerging therapy that combines heterogeneous techniques. The aim of the study was to provide a nationwide contemporary snapshot of clinical practice and CDT-related outcomes.
METHODS: This Investigator-initiated multicenter registry aimed to include consecutive patients with intermediate-high risk (IHR) or high-risk (HR), acute PE eligible for CDT. The primary outcome of the study was in-hospital all-cause death.
RESULTS: A total of 253 patients were included, of whom 93 (36.8%) had HR-PE, and 160 (63.2%) had IHR-PE with a mean age of 62.3±15.1 years. Local thrombolysis was performed in 70.8% and aspiration thrombectomy in 51.8%, with 23.3% of patients receiving both. However, aspiration thrombectomy was favored in the HR-PE cohort (80.6% vs 35%; P<.001). Only 51 patients (20.2%) underwent CDT with specific PE devices. The success rate for CDT was 90.9% (98.1% of IHR-PE patients vs 78.5% of HR-PE patients, P<.001). In-hospital mortality was 15.5%, and was highly concentrated in the HR-PE patients (37.6%) and significantly lower in IHR-PE patients (2.5%), P<.001. Long-term (24-month) mortality was 40.2% in HR-PE patients vs 8.2% in IHR-PE patients (P<.001).
CONCLUSIONS: Despite the high success rate for CDT, in-hospital mortality in HR-PE is still high (37.6%) compared with very low IHR-PE mortality (2.5%).
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
---|---|
Enthalten in: |
Revista espanola de cardiologia (English ed.) - 77(2024), 2 vom: 27. Jan., Seite 138-147 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Salinas, Pablo [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 29.01.2024 Date Revised 29.01.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.rec.2023.06.005 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM358563089 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM358563089 | ||
003 | DE-627 | ||
005 | 20240129231835.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.rec.2023.06.005 |2 doi | |
028 | 5 | 2 | |a pubmed24n1274.xml |
035 | |a (DE-627)NLM358563089 | ||
035 | |a (NLM)37354942 | ||
035 | |a (PII)S1885-5857(23)00166-4 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Salinas, Pablo |e verfasserin |4 aut | |
245 | 1 | 0 | |a Catheter-directed therapy for acute pulmonary embolism |b results of a multicenter national registry |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 29.01.2024 | ||
500 | |a Date Revised 29.01.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved. | ||
520 | |a INTRODUCTION AND OBJECTIVES: Catheter-directed therapy (CDT) for acute pulmonary embolism (PE) is an emerging therapy that combines heterogeneous techniques. The aim of the study was to provide a nationwide contemporary snapshot of clinical practice and CDT-related outcomes | ||
520 | |a METHODS: This Investigator-initiated multicenter registry aimed to include consecutive patients with intermediate-high risk (IHR) or high-risk (HR), acute PE eligible for CDT. The primary outcome of the study was in-hospital all-cause death | ||
520 | |a RESULTS: A total of 253 patients were included, of whom 93 (36.8%) had HR-PE, and 160 (63.2%) had IHR-PE with a mean age of 62.3±15.1 years. Local thrombolysis was performed in 70.8% and aspiration thrombectomy in 51.8%, with 23.3% of patients receiving both. However, aspiration thrombectomy was favored in the HR-PE cohort (80.6% vs 35%; P<.001). Only 51 patients (20.2%) underwent CDT with specific PE devices. The success rate for CDT was 90.9% (98.1% of IHR-PE patients vs 78.5% of HR-PE patients, P<.001). In-hospital mortality was 15.5%, and was highly concentrated in the HR-PE patients (37.6%) and significantly lower in IHR-PE patients (2.5%), P<.001. Long-term (24-month) mortality was 40.2% in HR-PE patients vs 8.2% in IHR-PE patients (P<.001) | ||
520 | |a CONCLUSIONS: Despite the high success rate for CDT, in-hospital mortality in HR-PE is still high (37.6%) compared with very low IHR-PE mortality (2.5%) | ||
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Embolectomy | |
650 | 4 | |a Embolectomía | |
650 | 4 | |a Embolia pulmonar | |
650 | 4 | |a Fibrinolytic therapy | |
650 | 4 | |a Pulmonary embolism | |
650 | 4 | |a Thrombectomy | |
650 | 4 | |a Thrombolytic therapy | |
650 | 4 | |a Tratamiento fibrinolítico | |
650 | 4 | |a Tratamiento trombolítico | |
650 | 4 | |a Trombectomía | |
650 | 7 | |a Fibrinolytic Agents |2 NLM | |
700 | 1 | |a Vázquez-Álvarez, María-Eugenia |e verfasserin |4 aut | |
700 | 1 | |a Salvatella, Neus |e verfasserin |4 aut | |
700 | 1 | |a Ruiz Quevedo, Valeriano |e verfasserin |4 aut | |
700 | 1 | |a Velázquez Martín, Maite |e verfasserin |4 aut | |
700 | 1 | |a Valero, Ernesto |e verfasserin |4 aut | |
700 | 1 | |a Rumiz, Eva |e verfasserin |4 aut | |
700 | 1 | |a Jurado-Román, Alfonso |e verfasserin |4 aut | |
700 | 1 | |a Lozano, Íñigo |e verfasserin |4 aut | |
700 | 1 | |a Gallardo, Fernando |e verfasserin |4 aut | |
700 | 1 | |a Amat-Santos, Ignacio J |e verfasserin |4 aut | |
700 | 1 | |a Lorenzo, Óscar |e verfasserin |4 aut | |
700 | 1 | |a Portero Portaz, Juan José |e verfasserin |4 aut | |
700 | 1 | |a Huanca, Mike |e verfasserin |4 aut | |
700 | 1 | |a Nombela-Franco, Luis |e verfasserin |4 aut | |
700 | 1 | |a Vaquerizo, Beatriz |e verfasserin |4 aut | |
700 | 1 | |a Ramallal Martínez, Raúl |e verfasserin |4 aut | |
700 | 1 | |a Maneiro Melón, Nicolás Manuel |e verfasserin |4 aut | |
700 | 1 | |a Sanchis, Juan |e verfasserin |4 aut | |
700 | 1 | |a Berenguer, Alberto |e verfasserin |4 aut | |
700 | 1 | |a Gallardo-López, Arsenio |e verfasserin |4 aut | |
700 | 1 | |a Gutiérrez-Ibañes, Enrique |e verfasserin |4 aut | |
700 | 1 | |a Mejía-Rentería, Hernán |e verfasserin |4 aut | |
700 | 1 | |a Córdoba-Soriano, Juan Gabriel |e verfasserin |4 aut | |
700 | 1 | |a Jiménez-Mazuecos, Jesús María |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Revista espanola de cardiologia (English ed.) |d 2010 |g 77(2024), 2 vom: 27. Jan., Seite 138-147 |w (DE-627)NLM206580851 |x 1885-5857 |7 nnns |
773 | 1 | 8 | |g volume:77 |g year:2024 |g number:2 |g day:27 |g month:01 |g pages:138-147 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.rec.2023.06.005 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 77 |j 2024 |e 2 |b 27 |c 01 |h 138-147 |