Micro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility spectrometry
© 2023. The Author(s)..
A new concept of paper-based device has been developed combining the advantages of cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The composite, named as NH2-UiO-66paper, has been developed for the isolation of synthetic cannabinoid receptor agonists (SCRAs) in oral fluids, trying to mimic the interactions of those compounds with the human CB1R and CB2R receptors, mainly governed by hydrogen bonding and π-interactions with serine and histidine residues. MOF selection (UiO-66) and functionalization of the ligand (2-aminoterephthalic acid) has been done according to the following criteria: (i) water stability of the selected MOF, and (ii) promoting appropriate interactions with SCRAs due to the MOF nature. NH2-UiO-66@paper composite has been characterized in depth and the results confirmed that the material is stable at the temperature selected for thermal desorption (230 °C). Furthermore, the developed method provided appropriate precision values (RSD < 12%) and a limit of detection as low as 10 ng using ion mobility spectrometry as analytical technique. Lastly, the method has been successfully applied to the isolation of several synthetic cannabinoids from oral fluids. This method claims to be an interesting approach for expanding the combination of MOFs with sustainable support and represents a promising alternative to sophisticated and non-portable systems due to the negligible sample treatment required and the simplicity of the operation, which can be applied with screening purposes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:190 |
|---|---|
| Enthalten in: |
Mikrochimica acta - 190(2023), 7 vom: 23. Juni, Seite 271 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Martínez-Pérez-Cejuela, Héctor [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Biological samples |
|---|
| Anmerkungen: |
Date Completed 26.06.2023 Date Revised 16.11.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00604-023-05844-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM35853027X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM35853027X | ||
| 003 | DE-627 | ||
| 005 | 20231226074938.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00604-023-05844-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1195.xml |
| 035 | |a (DE-627)NLM35853027X | ||
| 035 | |a (NLM)37351649 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Martínez-Pérez-Cejuela, Héctor |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Micro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility spectrometry |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.06.2023 | ||
| 500 | |a Date Revised 16.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a A new concept of paper-based device has been developed combining the advantages of cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The composite, named as NH2-UiO-66paper, has been developed for the isolation of synthetic cannabinoid receptor agonists (SCRAs) in oral fluids, trying to mimic the interactions of those compounds with the human CB1R and CB2R receptors, mainly governed by hydrogen bonding and π-interactions with serine and histidine residues. MOF selection (UiO-66) and functionalization of the ligand (2-aminoterephthalic acid) has been done according to the following criteria: (i) water stability of the selected MOF, and (ii) promoting appropriate interactions with SCRAs due to the MOF nature. NH2-UiO-66@paper composite has been characterized in depth and the results confirmed that the material is stable at the temperature selected for thermal desorption (230 °C). Furthermore, the developed method provided appropriate precision values (RSD < 12%) and a limit of detection as low as 10 ng using ion mobility spectrometry as analytical technique. Lastly, the method has been successfully applied to the isolation of several synthetic cannabinoids from oral fluids. This method claims to be an interesting approach for expanding the combination of MOFs with sustainable support and represents a promising alternative to sophisticated and non-portable systems due to the negligible sample treatment required and the simplicity of the operation, which can be applied with screening purposes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Biological samples | |
| 650 | 4 | |a Drugs | |
| 650 | 4 | |a Paper-based devices | |
| 650 | 4 | |a Solid-phase extraction | |
| 650 | 4 | |a UiO-66 | |
| 650 | 7 | |a UiO-66 |2 NLM | |
| 650 | 7 | |a Metal-Organic Frameworks |2 NLM | |
| 650 | 7 | |a Phthalic Acids |2 NLM | |
| 650 | 7 | |a Organometallic Compounds |2 NLM | |
| 650 | 7 | |a Cannabinoids |2 NLM | |
| 700 | 1 | |a García-Atienza, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Simó-Alfonso, Ernesto Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Herrero-Martínez, José Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Armenta, Sergio |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Mikrochimica acta |d 1994 |g 190(2023), 7 vom: 23. Juni, Seite 271 |w (DE-627)NLM000043036 |x 1436-5073 |7 nnns |
| 773 | 1 | 8 | |g volume:190 |g year:2023 |g number:7 |g day:23 |g month:06 |g pages:271 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00604-023-05844-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 190 |j 2023 |e 7 |b 23 |c 06 |h 271 | ||