Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder. Severe liver injury has rarely been reported, although liver enzyme elevation is a common complication of AOSD. We herein report four cases of relapsed AOSD with severe liver disorder by tapering or terminating corticosteroids. Liver specimens revealed robust infiltration of inflammatory cells throughout the lobule, especially cluster of differentiation (CD) 8-positive cells. Relapsed AOSD was refractory to corticosteroid reintroduction and required immunosuppressants. Severe liver injury with AOSD is pathologically characterized by extensive lobular infiltration of CD8-positive cells, and we should consider additive immunosuppressive agents on corticosteroids for treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 63(2024), 4 vom: 15. Feb., Seite 503-511 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kurokawa, Miho [VerfasserIn] |
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| Links: |
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| Themen: |
Acute liver injury |
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| Anmerkungen: |
Date Completed 16.02.2024 Date Revised 16.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.2043-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM35845882X |
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| 520 | |a Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder. Severe liver injury has rarely been reported, although liver enzyme elevation is a common complication of AOSD. We herein report four cases of relapsed AOSD with severe liver disorder by tapering or terminating corticosteroids. Liver specimens revealed robust infiltration of inflammatory cells throughout the lobule, especially cluster of differentiation (CD) 8-positive cells. Relapsed AOSD was refractory to corticosteroid reintroduction and required immunosuppressants. Severe liver injury with AOSD is pathologically characterized by extensive lobular infiltration of CD8-positive cells, and we should consider additive immunosuppressive agents on corticosteroids for treatment | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Hioki, Tomonobu |e verfasserin |4 aut | |
| 700 | 1 | |a Aoyagi, Tomomi |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Motoi |e verfasserin |4 aut | |
| 700 | 1 | |a Imoto, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Goya, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Masatake |e verfasserin |4 aut | |
| 700 | 1 | |a Kohjima, Motoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Yoshihiro |e verfasserin |4 aut | |
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