Injectable Ventral Spinal Stimulator Evokes Programmable and Biomimetic Hindlimb Motion
Spinal cord neuromodulation can restore partial to complete loss of motor functions associated with neuromotor disease and trauma. Current technologies have made substantial progress but have limitations as dorsal epidural or intraspinal devices that are either remote to ventral motor neurons or subject to surgical intervention in the spinal tissue. Here, we describe a flexible and stretchable spinal stimulator design with nanoscale thickness that can be implanted by minimally invasive injection through a polymeric catheter to target the ventral spinal space of mice. Ventrolaterally implanted devices exhibited substantially lower stimulation threshold currents and more precise recruitment of motor pools than did comparable dorsal epidural implants. Functionally relevant and novel hindlimb movements were achieved via specific stimulation patterns of the electrodes. This approach holds translational potential for improving controllable limb function following spinal cord injury or neuromotor disease.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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Enthalten in: |
Nano letters - 23(2023), 13 vom: 12. Juli, Seite 6184-6192 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Lin, Dingchang [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 13.07.2023 Date Revised 18.07.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1021/acs.nanolett.3c01806 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM358397219 |
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520 | |a Spinal cord neuromodulation can restore partial to complete loss of motor functions associated with neuromotor disease and trauma. Current technologies have made substantial progress but have limitations as dorsal epidural or intraspinal devices that are either remote to ventral motor neurons or subject to surgical intervention in the spinal tissue. Here, we describe a flexible and stretchable spinal stimulator design with nanoscale thickness that can be implanted by minimally invasive injection through a polymeric catheter to target the ventral spinal space of mice. Ventrolaterally implanted devices exhibited substantially lower stimulation threshold currents and more precise recruitment of motor pools than did comparable dorsal epidural implants. Functionally relevant and novel hindlimb movements were achieved via specific stimulation patterns of the electrodes. This approach holds translational potential for improving controllable limb function following spinal cord injury or neuromotor disease | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
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650 | 4 | |a epidural electrical stimulation | |
650 | 4 | |a spinal cord injury | |
650 | 4 | |a spinal interface | |
650 | 4 | |a ventrolateral implantation | |
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700 | 1 | |a Wang, Chonghe |e verfasserin |4 aut | |
700 | 1 | |a Park, Hong-Gyu |e verfasserin |4 aut | |
700 | 1 | |a Lieber, Charles M |e verfasserin |4 aut | |
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