Waitlist and Transplant Outcomes in Organ Donation After Circulatory Death : Trends in the United States
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved..
OBJECTIVES: To summarize waitlist and transplant outcomes in kidney, liver, lung, and heart transplantation using organ donation after circulatory death (DCD).
BACKGROUND: DCD has expanded the donor pool for solid organ transplantation, most recently for heart transplantation.
METHODS: The United Network for Organ Sharing registry was used to identify adult transplant candidates and recipients in the most recent allocation policy eras for kidney, liver, lung, and heart transplantation. Transplant candidates and recipients were grouped by acceptance criteria for DCD versus brain-dead donors [donation after brain death (DBD)] only and DCD versus DBD transplant, respectively. Propensity matching and competing-risks regression was used to model waitlist outcomes. Survival was modeled using propensity matching and Kaplan-Meier and Cox regression analysis.
RESULTS: DCD transplant volumes have increased significantly across all organs. Liver candidates listed for DCD organs were more likely to undergo transplantation compared with propensity-matched candidates listed for DBD only, and heart and liver transplant candidates listed for DCD were less likely to experience death or clinical deterioration requiring waitlist inactivation. Propensity-matched DCD recipients demonstrated an increased mortality risk up to 5 years after liver and kidney transplantation and up to 3 years after lung transplantation compared with DBD. There was no difference in 1-year mortality between DCD and DBD heart transplantation.
CONCLUSIONS: DCD continues to expand access to transplantation and improves waitlist outcomes for liver and heart transplant candidates. Despite an increased risk for mortality with DCD kidney, liver, and lung transplantation, survival with DCD transplant remains acceptable.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:278 |
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| Enthalten in: |
Annals of surgery - 278(2023), 4 vom: 01. Okt., Seite 609-620 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kwon, Jennie H [VerfasserIn] |
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| Anmerkungen: |
Date Completed 11.09.2023 Date Revised 15.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/SLA.0000000000005947 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358362709 |
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| 100 | 1 | |a Kwon, Jennie H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Waitlist and Transplant Outcomes in Organ Donation After Circulatory Death |b Trends in the United States |
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| 500 | |a Date Completed 11.09.2023 | ||
| 500 | |a Date Revised 15.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To summarize waitlist and transplant outcomes in kidney, liver, lung, and heart transplantation using organ donation after circulatory death (DCD) | ||
| 520 | |a BACKGROUND: DCD has expanded the donor pool for solid organ transplantation, most recently for heart transplantation | ||
| 520 | |a METHODS: The United Network for Organ Sharing registry was used to identify adult transplant candidates and recipients in the most recent allocation policy eras for kidney, liver, lung, and heart transplantation. Transplant candidates and recipients were grouped by acceptance criteria for DCD versus brain-dead donors [donation after brain death (DBD)] only and DCD versus DBD transplant, respectively. Propensity matching and competing-risks regression was used to model waitlist outcomes. Survival was modeled using propensity matching and Kaplan-Meier and Cox regression analysis | ||
| 520 | |a RESULTS: DCD transplant volumes have increased significantly across all organs. Liver candidates listed for DCD organs were more likely to undergo transplantation compared with propensity-matched candidates listed for DBD only, and heart and liver transplant candidates listed for DCD were less likely to experience death or clinical deterioration requiring waitlist inactivation. Propensity-matched DCD recipients demonstrated an increased mortality risk up to 5 years after liver and kidney transplantation and up to 3 years after lung transplantation compared with DBD. There was no difference in 1-year mortality between DCD and DBD heart transplantation | ||
| 520 | |a CONCLUSIONS: DCD continues to expand access to transplantation and improves waitlist outcomes for liver and heart transplant candidates. Despite an increased risk for mortality with DCD kidney, liver, and lung transplantation, survival with DCD transplant remains acceptable | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Blanding, Walker M |e verfasserin |4 aut | |
| 700 | 1 | |a Shorbaji, Khaled |e verfasserin |4 aut | |
| 700 | 1 | |a Scalea, Joseph R |e verfasserin |4 aut | |
| 700 | 1 | |a Gibney, Barry C |e verfasserin |4 aut | |
| 700 | 1 | |a Baliga, Prabhakar K |e verfasserin |4 aut | |
| 700 | 1 | |a Kilic, Arman |e verfasserin |4 aut | |
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