SARS-CoV-2 targets the liver and manipulates glucose metabolism
Copyright © 2023 Elsevier Ltd. All rights reserved..
A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism of SARS-CoV-2. We also comment on the clinical implications of the bidirectional connection between COVID-19 and noncommunicable diseases.
| Errataetall: |
CommentOn: Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2217119120. - PMID 37186819 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Trends in molecular medicine - 29(2023), 9 vom: 15. Sept., Seite 681-683 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pirola, Carlos J [VerfasserIn] |
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| Links: |
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| Themen: |
Comment |
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| Anmerkungen: |
Date Completed 14.08.2023 Date Revised 28.08.2023 published: Print-Electronic CommentOn: Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2217119120. - PMID 37186819 Citation Status MEDLINE |
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| doi: |
10.1016/j.molmed.2023.06.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358319277 |
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| 520 | |a A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism of SARS-CoV-2. We also comment on the clinical implications of the bidirectional connection between COVID-19 and noncommunicable diseases | ||
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