Satellite cell contribution to disease pathology in Duchenne muscular dystrophy
Copyright © 2023 Kodippili and Rudnicki..
Progressive muscle weakness and degeneration characterize Duchenne muscular dystrophy (DMD), a lethal, x-linked neuromuscular disorder that affects 1 in 5,000 boys. Loss of dystrophin protein leads to recurrent muscle degeneration, progressive fibrosis, chronic inflammation, and dysfunction of skeletal muscle resident stem cells, called satellite cells. Unfortunately, there is currently no cure for DMD. In this mini review, we discuss how satellite cells in dystrophic muscle are functionally impaired, and how this contributes to the DMD pathology, and the tremendous potential of restoring endogenous satellite cell function as a viable treatment strategy to treat this debilitating and fatal disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in physiology - 14(2023) vom: 01., Seite 1180980 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kodippili, Kasun [VerfasserIn] |
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| Links: |
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| Themen: |
Asymmetric cell division |
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| Anmerkungen: |
Date Revised 19.06.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fphys.2023.1180980 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM358259835 |
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| 520 | |a Progressive muscle weakness and degeneration characterize Duchenne muscular dystrophy (DMD), a lethal, x-linked neuromuscular disorder that affects 1 in 5,000 boys. Loss of dystrophin protein leads to recurrent muscle degeneration, progressive fibrosis, chronic inflammation, and dysfunction of skeletal muscle resident stem cells, called satellite cells. Unfortunately, there is currently no cure for DMD. In this mini review, we discuss how satellite cells in dystrophic muscle are functionally impaired, and how this contributes to the DMD pathology, and the tremendous potential of restoring endogenous satellite cell function as a viable treatment strategy to treat this debilitating and fatal disease | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a muscle regeneration | |
| 650 | 4 | |a myogenesis | |
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| 650 | 4 | |a symmetric cell division | |
| 700 | 1 | |a Rudnicki, Michael A |e verfasserin |4 aut | |
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