Constitutive Expression of Hif2α Confers Acute O2 Sensitivity to Carotid Body Glomus Cells
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG..
Acute oxygen (O2) sensing and adaptation to hypoxia are essential for physiological homeostasis. The prototypical acute O2 sensing organ is the carotid body, which contains chemosensory glomus cells expressing O2-sensitive K+ channels. Inhibition of these channels during hypoxia leads to cell depolarization, transmitter release, and activation of afferent sensory fibers terminating in the brain stem respiratory and autonomic centers. Focusing on recent data, here we discuss the special sensitivity of glomus cell mitochondria to changes in O2 tension due to Hif2α-dependent expression of several atypical mitochondrial electron transport chain subunits and enzymes. These are responsible for an accelerated oxidative metabolism and the strict dependence of mitochondrial complex IV activity on O2 availability. We report that ablation of Epas1 (the gene coding Hif2α) causes a selective downregulation of the atypical mitochondrial genes and a strong inhibition of glomus cell acute responsiveness to hypoxia. Our observations indicate that Hif2α expression is required for the characteristic metabolic profile of glomus cells and provide a mechanistic explanation for the acute O2 regulation of breathing.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1427 |
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| Enthalten in: |
Advances in experimental medicine and biology - 1427(2023) vom: 15., Seite 153-162 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Colinas, Olalla [VerfasserIn] |
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| Links: |
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| Themen: |
Acute oxygen sensing |
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| Anmerkungen: |
Date Completed 19.06.2023 Date Revised 19.06.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-3-031-32371-3_17 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM358239338 |
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| 520 | |a © 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG. | ||
| 520 | |a Acute oxygen (O2) sensing and adaptation to hypoxia are essential for physiological homeostasis. The prototypical acute O2 sensing organ is the carotid body, which contains chemosensory glomus cells expressing O2-sensitive K+ channels. Inhibition of these channels during hypoxia leads to cell depolarization, transmitter release, and activation of afferent sensory fibers terminating in the brain stem respiratory and autonomic centers. Focusing on recent data, here we discuss the special sensitivity of glomus cell mitochondria to changes in O2 tension due to Hif2α-dependent expression of several atypical mitochondrial electron transport chain subunits and enzymes. These are responsible for an accelerated oxidative metabolism and the strict dependence of mitochondrial complex IV activity on O2 availability. We report that ablation of Epas1 (the gene coding Hif2α) causes a selective downregulation of the atypical mitochondrial genes and a strong inhibition of glomus cell acute responsiveness to hypoxia. Our observations indicate that Hif2α expression is required for the characteristic metabolic profile of glomus cells and provide a mechanistic explanation for the acute O2 regulation of breathing | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute oxygen sensing | |
| 650 | 4 | |a Carotid body | |
| 650 | 4 | |a Cell physiology | |
| 650 | 4 | |a Glomus cells | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Mitochondrial subunit isoforms | |
| 650 | 7 | |a Oxygen |2 NLM | |
| 650 | 7 | |a S88TT14065 |2 NLM | |
| 700 | 1 | |a Moreno-Domínguez, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Ortega-Sáenz, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a López-Barneo, José |e verfasserin |4 aut | |
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