Prognostic factors in patients with endometrial cancer with isolated lymphatic recurrence
© IGCS and ESGO 2023. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: To analyze the clinicopathological features and outcomes in patients with endometrial cancer with isolated lymphatic recurrence after lymphadenectomy, stratified by different isolated lymphatic recurrence sites and treatment approaches.
METHODS: We retrospectively reviewed all surgically treated patients with endometrial cancer, identifying those with recurrence. We defined primary isolated lymphatic recurrence as the first and unique evidence of recurrence in lymph node-bearing areas, without concomitant vaginal, hematogenous, or peritoneal recurrence. Isolated lymphatic recurrences were classified as pelvic, para-aortic, distant, or multiple sites. Our primary outcome was cause-specific survival after diagnosis of the recurrence.
RESULTS: Among 4216 patients with surgically staged endometrial cancer, we identified 66 (1.6%) women with isolated lymphatic recurrence. The overall median cause-specific survival for patients with isolated lymphatic recurrence was 24 months. Although cause-specific survival was not significantly different between the four isolated lymphatic recurrence groups (p=0.21), 7 of 15 (47%) patients with isolated lymphatic recurrence in the para-aortic area were long-term survivors. At multivariate Cox regression, the absence of lymphovascular space invasion and grade 1 histology in the primary tumor were significantly associated with improved cause-specific survival. In addition, patients with isolated lymphatic recurrence who underwent surgery for recurrence (with/without other associated therapies) had improved cause-specific survival compared with patients who did not undergo surgery, also after adjusting for age.
CONCLUSIONS: Low-grade histology and absence of lymphovascular space invasion in the primary tumor were predictors of improved prognosis in patients with endometrial cancer with isolated lymphatic recurrence. In addition, in this retrospective cohort, patients with isolated lymphatic recurrence who were selected for eradicative surgical treatment had improved cause-specific survival.
| Errataetall: |
CommentIn: Int J Gynecol Cancer. 2023 Aug 7;33(8):1179-1180. - PMID 37460219 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 33(2023), 8 vom: 07. Aug., Seite 1169-1178 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Capasso, Ilaria [VerfasserIn] |
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| Links: |
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| Themen: |
Endometrial Neoplasms |
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| Anmerkungen: |
Date Completed 09.08.2023 Date Revised 10.08.2023 published: Electronic CommentIn: Int J Gynecol Cancer. 2023 Aug 7;33(8):1179-1180. - PMID 37460219 Citation Status MEDLINE |
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| doi: |
10.1136/ijgc-2023-004435 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358232643 |
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| 245 | 1 | 0 | |a Prognostic factors in patients with endometrial cancer with isolated lymphatic recurrence |
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| 500 | |a Date Revised 10.08.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a CommentIn: Int J Gynecol Cancer. 2023 Aug 7;33(8):1179-1180. - PMID 37460219 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © IGCS and ESGO 2023. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: To analyze the clinicopathological features and outcomes in patients with endometrial cancer with isolated lymphatic recurrence after lymphadenectomy, stratified by different isolated lymphatic recurrence sites and treatment approaches | ||
| 520 | |a METHODS: We retrospectively reviewed all surgically treated patients with endometrial cancer, identifying those with recurrence. We defined primary isolated lymphatic recurrence as the first and unique evidence of recurrence in lymph node-bearing areas, without concomitant vaginal, hematogenous, or peritoneal recurrence. Isolated lymphatic recurrences were classified as pelvic, para-aortic, distant, or multiple sites. Our primary outcome was cause-specific survival after diagnosis of the recurrence | ||
| 520 | |a RESULTS: Among 4216 patients with surgically staged endometrial cancer, we identified 66 (1.6%) women with isolated lymphatic recurrence. The overall median cause-specific survival for patients with isolated lymphatic recurrence was 24 months. Although cause-specific survival was not significantly different between the four isolated lymphatic recurrence groups (p=0.21), 7 of 15 (47%) patients with isolated lymphatic recurrence in the para-aortic area were long-term survivors. At multivariate Cox regression, the absence of lymphovascular space invasion and grade 1 histology in the primary tumor were significantly associated with improved cause-specific survival. In addition, patients with isolated lymphatic recurrence who underwent surgery for recurrence (with/without other associated therapies) had improved cause-specific survival compared with patients who did not undergo surgery, also after adjusting for age | ||
| 520 | |a CONCLUSIONS: Low-grade histology and absence of lymphovascular space invasion in the primary tumor were predictors of improved prognosis in patients with endometrial cancer with isolated lymphatic recurrence. In addition, in this retrospective cohort, patients with isolated lymphatic recurrence who were selected for eradicative surgical treatment had improved cause-specific survival | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Endometrial Neoplasms | |
| 650 | 4 | |a Lymph Nodes | |
| 650 | 4 | |a Neoplasm Recurrence, Local | |
| 650 | 4 | |a Surgical Oncology | |
| 700 | 1 | |a Garzon, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Sanjeev |e verfasserin |4 aut | |
| 700 | 1 | |a Weaver, Amy L |e verfasserin |4 aut | |
| 700 | 1 | |a Mc Gree, Michaela |e verfasserin |4 aut | |
| 700 | 1 | |a De Vitis, Luigi Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Uccella, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Petersen, Ivy |e verfasserin |4 aut | |
| 700 | 1 | |a Glaser, Gretchen |e verfasserin |4 aut | |
| 700 | 1 | |a Langstraat, Carrie |e verfasserin |4 aut | |
| 700 | 1 | |a Scambia, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Fanfani, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Mariani, Andrea |e verfasserin |4 aut | |
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