Prevalence and clinical characteristics of non-malignant CT detected incidental findings in the SUMMIT lung cancer screening cohort
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
BACKGROUND: Pulmonary and extrapulmonary incidental findings are frequently identified on CT scans performed for lung cancer screening. Uncertainty regarding their clinical significance and how and when such findings should be reported back to clinicians and participants persists. We examined the prevalence of non-malignant incidental findings within a lung cancer screening cohort and investigated the morbidity and relevant risk factors associated with incidental findings. We quantified the primary and secondary care referrals generated by our protocol.
METHODS: The SUMMIT study (NCT03934866) is a prospective observational cohort study to examine the performance of delivering a low-dose CT (LDCT) screening service to a high-risk population. Spirometry, blood pressure, height/weight and respiratory history were assessed as part of a Lung Health Check. Individuals at high risk of lung cancer were offered an LDCT and returned for two further annual visits. This analysis is a prospective evaluation of the standardised reporting and management protocol for incidental findings developed for the study on the baseline LDCT.
RESULTS: In 11 115 participants included in this analysis, the most common incidental findings were coronary artery calcification (64.2%) and emphysema (33.4%). From our protocolised management approach, the number of participants requiring review for clinically relevant findings in primary care was 1 in 20, and the number potentially requiring review in secondary care was 1 in 25.
CONCLUSIONS: Incidental findings are common in lung cancer screening and can be associated with reported symptoms and comorbidities. A standardised reporting protocol allows systematic assessment and standardises onward management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
BMJ open respiratory research - 10(2023), 1 vom: 16. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tisi, Sophie [VerfasserIn] |
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| Links: |
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| Themen: |
Imaging/CT MRI etc |
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| Anmerkungen: |
Date Completed 19.06.2023 Date Revised 20.03.2024 published: Print ClinicalTrials.gov: NCT03934866 Citation Status MEDLINE |
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| doi: |
10.1136/bmjresp-2023-001664 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358232562 |
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| 100 | 1 | |a Tisi, Sophie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalence and clinical characteristics of non-malignant CT detected incidental findings in the SUMMIT lung cancer screening cohort |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 19.06.2023 | ||
| 500 | |a Date Revised 20.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT03934866 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a BACKGROUND: Pulmonary and extrapulmonary incidental findings are frequently identified on CT scans performed for lung cancer screening. Uncertainty regarding their clinical significance and how and when such findings should be reported back to clinicians and participants persists. We examined the prevalence of non-malignant incidental findings within a lung cancer screening cohort and investigated the morbidity and relevant risk factors associated with incidental findings. We quantified the primary and secondary care referrals generated by our protocol | ||
| 520 | |a METHODS: The SUMMIT study (NCT03934866) is a prospective observational cohort study to examine the performance of delivering a low-dose CT (LDCT) screening service to a high-risk population. Spirometry, blood pressure, height/weight and respiratory history were assessed as part of a Lung Health Check. Individuals at high risk of lung cancer were offered an LDCT and returned for two further annual visits. This analysis is a prospective evaluation of the standardised reporting and management protocol for incidental findings developed for the study on the baseline LDCT | ||
| 520 | |a RESULTS: In 11 115 participants included in this analysis, the most common incidental findings were coronary artery calcification (64.2%) and emphysema (33.4%). From our protocolised management approach, the number of participants requiring review for clinically relevant findings in primary care was 1 in 20, and the number potentially requiring review in secondary care was 1 in 25 | ||
| 520 | |a CONCLUSIONS: Incidental findings are common in lung cancer screening and can be associated with reported symptoms and comorbidities. A standardised reporting protocol allows systematic assessment and standardises onward management | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Imaging/CT MRI etc | |
| 650 | 4 | |a Lung Cancer | |
| 700 | 1 | |a Creamer, Andrew W |e verfasserin |4 aut | |
| 700 | 1 | |a Dickson, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Horst, Carolyn |e verfasserin |4 aut | |
| 700 | 1 | |a Quaife, Samantha |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Helen |e verfasserin |4 aut | |
| 700 | 1 | |a Verghese, Priyam |e verfasserin |4 aut | |
| 700 | 1 | |a Gyertson, Kylie |e verfasserin |4 aut | |
| 700 | 1 | |a Bowyer, Vicky |e verfasserin |4 aut | |
| 700 | 1 | |a Levermore, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Hacker, Anne-Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Teague, Jonathon |e verfasserin |4 aut | |
| 700 | 1 | |a Farrelly, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Nair, Arjun |e verfasserin |4 aut | |
| 700 | 1 | |a Devaraj, Anand |e verfasserin |4 aut | |
| 700 | 1 | |a Hackshaw, Allan |e verfasserin |4 aut | |
| 700 | 1 | |a Hurst, John R |e verfasserin |4 aut | |
| 700 | 0 | |a SUMMIT Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Janes, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Janes, Sam M |e investigator |4 oth | |
| 700 | 1 | |a Dickson, Jennifer L |e investigator |4 oth | |
| 700 | 1 | |a Horst, Carolyn |e investigator |4 oth | |
| 700 | 1 | |a Tisi, Sophie |e investigator |4 oth | |
| 700 | 1 | |a Hall, Helen |e investigator |4 oth | |
| 700 | 1 | |a Verghese, Priyam |e investigator |4 oth | |
| 700 | 1 | |a Creamer, Andrew |e investigator |4 oth | |
| 700 | 1 | |a Callender, Thomas |e investigator |4 oth | |
| 700 | 1 | |a Prendecki, Ruth |e investigator |4 oth | |
| 700 | 1 | |a Bhamani, Amyn |e investigator |4 oth | |
| 700 | 1 | |a Ruparel, Mamta |e investigator |4 oth | |
| 700 | 1 | |a Hackshaw, Allan |e investigator |4 oth | |
| 700 | 1 | |a Farrelly, Laura |e investigator |4 oth | |
| 700 | 1 | |a Teague, Jon |e investigator |4 oth | |
| 700 | 1 | |a Mullin, Anne-Marie |e investigator |4 oth | |
| 700 | 1 | |a Chan, Kitty |e investigator |4 oth | |
| 700 | 1 | |a Sarpong, Rachael |e investigator |4 oth | |
| 700 | 1 | |a Suresh, Malavika |e investigator |4 oth | |
| 700 | 1 | |a Quaife, Samantha L |e investigator |4 oth | |
| 700 | 1 | |a Nair, Arjun |e investigator |4 oth | |
| 700 | 1 | |a Devaraj, Anand |e investigator |4 oth | |
| 700 | 1 | |a Gyertson, Kylie |e investigator |4 oth | |
| 700 | 1 | |a Bowyer, Vicky |e investigator |4 oth | |
| 700 | 1 | |a El-Emir, Ethaar |e investigator |4 oth | |
| 700 | 1 | |a Airebamen, Judy |e investigator |4 oth | |
| 700 | 1 | |a Cotton, Alice |e investigator |4 oth | |
| 700 | 1 | |a Phua, Kaylene |e investigator |4 oth | |
| 700 | 1 | |a Murali, Elodie |e investigator |4 oth | |
| 700 | 1 | |a Mehta, Simranjit |e investigator |4 oth | |
| 700 | 1 | |a Zylstra, Janine |e investigator |4 oth | |
| 700 | 1 | |a Parry-Billings, Karen |e investigator |4 oth | |
| 700 | 1 | |a Ife, Columbus |e investigator |4 oth | |
| 700 | 1 | |a Neville, April |e investigator |4 oth | |
| 700 | 1 | |a Robinson, Paul |e investigator |4 oth | |
| 700 | 1 | |a Green, Laura |e investigator |4 oth | |
| 700 | 1 | |a Hanif, Zahra |e investigator |4 oth | |
| 700 | 1 | |a Kiconco, Helen |e investigator |4 oth | |
| 700 | 1 | |a McEwen, Ricardo |e investigator |4 oth | |
| 700 | 1 | |a Arancon, Dominique |e investigator |4 oth | |
| 700 | 1 | |a Beech, Nicholas |e investigator |4 oth | |
| 700 | 1 | |a Ovayolu, Derya |e investigator |4 oth | |
| 700 | 1 | |a Hosein, Christine |e investigator |4 oth | |
| 700 | 1 | |a Enes, Sylvia Patricia |e investigator |4 oth | |
| 700 | 1 | |a Neville, Qin April |e investigator |4 oth | |
| 700 | 1 | |a Rowlands, Jane |e investigator |4 oth | |
| 700 | 1 | |a Samson, Aashna |e investigator |4 oth | |
| 700 | 1 | |a Patel, Urja |e investigator |4 oth | |
| 700 | 1 | |a Hoque, Fahmida |e investigator |4 oth | |
| 700 | 1 | |a Pervez, Hina |e investigator |4 oth | |
| 700 | 1 | |a Nnorom, Sofia |e investigator |4 oth | |
| 700 | 1 | |a Miah, Moksud |e investigator |4 oth | |
| 700 | 1 | |a McKee, Julian |e investigator |4 oth | |
| 700 | 1 | |a Clark, Mark |e investigator |4 oth | |
| 700 | 1 | |a Eng, Jeannie |e investigator |4 oth | |
| 700 | 1 | |a Bojang, Fanta |e investigator |4 oth | |
| 700 | 1 | |a Levermore, Claire |e investigator |4 oth | |
| 700 | 1 | |a Patel, Anant |e investigator |4 oth | |
| 700 | 1 | |a Lock, Sara |e investigator |4 oth | |
| 700 | 1 | |a Banka, Rajesh |e investigator |4 oth | |
| 700 | 1 | |a Bhowmik, Angshu |e investigator |4 oth | |
| 700 | 1 | |a Ekeowa, Ugo |e investigator |4 oth | |
| 700 | 1 | |a Mangera, Zaheer |e investigator |4 oth | |
| 700 | 1 | |a Ricketts, William M |e investigator |4 oth | |
| 700 | 1 | |a Navani, Neal |e investigator |4 oth | |
| 700 | 1 | |a O'Shaughnessy, Terry |e investigator |4 oth | |
| 700 | 1 | |a Cash, Charlotte |e investigator |4 oth | |
| 700 | 1 | |a Taylor, Magali |e investigator |4 oth | |
| 700 | 1 | |a Hare, Samanjit |e investigator |4 oth | |
| 700 | 1 | |a Aziz, Tunku |e investigator |4 oth | |
| 700 | 1 | |a Ellis, Stephen |e investigator |4 oth | |
| 700 | 1 | |a Edey, Anthony |e investigator |4 oth | |
| 700 | 1 | |a Robinson, Graham |e investigator |4 oth | |
| 700 | 1 | |a Villanueva, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Robbie, Hasti |e investigator |4 oth | |
| 700 | 1 | |a Stefan, Elena |e investigator |4 oth | |
| 700 | 1 | |a Sayer, Charlie |e investigator |4 oth | |
| 700 | 1 | |a Screaton, Nick |e investigator |4 oth | |
| 700 | 1 | |a Nundlall, Navinah |e investigator |4 oth | |
| 700 | 1 | |a Gallagher, Lyndsey |e investigator |4 oth | |
| 700 | 1 | |a Crossingham, Andrew |e investigator |4 oth | |
| 700 | 1 | |a Buchan, Thea |e investigator |4 oth | |
| 700 | 1 | |a Limani, Tanita |e investigator |4 oth | |
| 700 | 1 | |a Gowers, Kate |e investigator |4 oth | |
| 700 | 1 | |a Davies, Kate |e investigator |4 oth | |
| 700 | 1 | |a McCabe, John |e investigator |4 oth | |
| 700 | 1 | |a Jacob, Joseph |e investigator |4 oth | |
| 700 | 1 | |a Sennett, Karen |e investigator |4 oth | |
| 700 | 1 | |a TaniaAnastasiadis, Andrew Perugia |e investigator |4 oth | |
| 700 | 1 | |a Rusius, James |e investigator |4 oth | |
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