Migraine Attacks Triggered by Ingestion of Watermelon
© 2023 S. Karger AG, Basel..
INTRODUCTION: Ingesting some foods can trigger headache attacks in migraine patients. Diet-sourced citrulline activates the <sc>l</sc>-arginine-nitric oxide pathway, acting on the pathophysiology of migraine.
METHODS: The study was a clinical trial, interventional, controlled, and with group comparison. The sample was non-random, composed of 38 volunteers with migraine and 38 without headache (control). Both groups ingested a portion of watermelon to determine the onset of headache attacks. Before and after ingesting watermelon, they underwent blood collections to determine serum nitrite levels.
RESULTS: There were 38 volunteers diagnosed with migraine without aura and 38 controls, whose mean age was, respectively, 22.4 ± 1.5 and 22.9 ± 3.1 years (p = 0.791). Headache was triggered by watermelon ingestion after 124.3 ± 20.5 min of ingestion in 23.7% (9/38) of the migraine volunteers and in none of the controls (p = 0.002). There was an increase in serum nitrite levels, both in migraine volunteers (23.4%) and in the control group (24.3%), after watermelon ingestion. This difference was significant (p < 0.001).
DISCUSSION: Watermelon ingestion triggered headache attacks in migraine patients and increased serum nitrite levels, attesting to a possible activation of the <sc>l</sc>-arginine-nitric oxide pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
European neurology - 86(2023), 4 vom: 01., Seite 250-255 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Silva-Néto, Raimundo Pereira [VerfasserIn] |
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| Links: |
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| Themen: |
31C4KY9ESH |
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| Anmerkungen: |
Date Completed 06.09.2023 Date Revised 11.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000531286 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358227879 |
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| 520 | |a © 2023 S. Karger AG, Basel. | ||
| 520 | |a INTRODUCTION: Ingesting some foods can trigger headache attacks in migraine patients. Diet-sourced citrulline activates the <sc>l</sc>-arginine-nitric oxide pathway, acting on the pathophysiology of migraine | ||
| 520 | |a METHODS: The study was a clinical trial, interventional, controlled, and with group comparison. The sample was non-random, composed of 38 volunteers with migraine and 38 without headache (control). Both groups ingested a portion of watermelon to determine the onset of headache attacks. Before and after ingesting watermelon, they underwent blood collections to determine serum nitrite levels | ||
| 520 | |a RESULTS: There were 38 volunteers diagnosed with migraine without aura and 38 controls, whose mean age was, respectively, 22.4 ± 1.5 and 22.9 ± 3.1 years (p = 0.791). Headache was triggered by watermelon ingestion after 124.3 ± 20.5 min of ingestion in 23.7% (9/38) of the migraine volunteers and in none of the controls (p = 0.002). There was an increase in serum nitrite levels, both in migraine volunteers (23.4%) and in the control group (24.3%), after watermelon ingestion. This difference was significant (p < 0.001) | ||
| 520 | |a DISCUSSION: Watermelon ingestion triggered headache attacks in migraine patients and increased serum nitrite levels, attesting to a possible activation of the <sc>l</sc>-arginine-nitric oxide pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Arginine | |
| 650 | 4 | |a Citruline | |
| 650 | 4 | |a Migraine | |
| 650 | 4 | |a Nitric oxide | |
| 650 | 4 | |a Watermelon | |
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| 650 | 7 | |a 94ZLA3W45F |2 NLM | |
| 650 | 7 | |a Nitric Oxide |2 NLM | |
| 650 | 7 | |a 31C4KY9ESH |2 NLM | |
| 650 | 7 | |a Nitrites |2 NLM | |
| 700 | 1 | |a Bezerra, Gabriela Leal |e verfasserin |4 aut | |
| 700 | 1 | |a Araújo, Natália Rebeca Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Sângela Fernandes |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Suyanne Kássia Soares |e verfasserin |4 aut | |
| 700 | 1 | |a Lima, Layana Karine Farias |e verfasserin |4 aut | |
| 700 | 1 | |a Soares, Adriana Almeida |e verfasserin |4 aut | |
| 700 | 1 | |a Lopes, Luciano Silva |e verfasserin |4 aut | |
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