Type 1 Cryoglobulinemic Vasculitis Due to Monoclonal Gammopathy of Undetermined Significance Successfully Treated by Bortezomib Plus Dexamethasone
Cryoglobulins are immunoglobulins that precipitate in cold conditions. Type I cryoglobulinemic vasculitis is associated with hematological malignancies. We herein report a case of steroid-resistant type 1 cryoglobulinemic vasculitis associated with monoclonal gammopathy of undetermined significance (MGUS) in a 47-year-old woman. By immunofixation of cryoglobulin, we found that the main component of cryoglobulin was the M protein due to MGUS, so treatment of MGUS was needed. Bortezomib+dexamethasone therapy resulted in a rapid decrease in cryoglobulin and improvement in the symptoms of cryoglobulinemic vasculitis. In refractory type I cryoglobulinemic vasculitis, treatment of the underlying gammaglobulinopathy should be considered.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 63(2024), 4 vom: 15. Feb., Seite 541-545 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kikuchi, Ryo [VerfasserIn] |
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| Links: |
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| Themen: |
69G8BD63PP |
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| Anmerkungen: |
Date Completed 16.02.2024 Date Revised 16.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.2053-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358178770 |
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| 520 | |a Cryoglobulins are immunoglobulins that precipitate in cold conditions. Type I cryoglobulinemic vasculitis is associated with hematological malignancies. We herein report a case of steroid-resistant type 1 cryoglobulinemic vasculitis associated with monoclonal gammopathy of undetermined significance (MGUS) in a 47-year-old woman. By immunofixation of cryoglobulin, we found that the main component of cryoglobulin was the M protein due to MGUS, so treatment of MGUS was needed. Bortezomib+dexamethasone therapy resulted in a rapid decrease in cryoglobulin and improvement in the symptoms of cryoglobulinemic vasculitis. In refractory type I cryoglobulinemic vasculitis, treatment of the underlying gammaglobulinopathy should be considered | ||
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| 700 | 1 | |a Onozawa, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nagai, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Satomi |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Ohigashi, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Mitamura, Shintaro |e verfasserin |4 aut | |
| 700 | 1 | |a Maeda, Taku |e verfasserin |4 aut | |
| 700 | 1 | |a Takakuwa, Emi |e verfasserin |4 aut | |
| 700 | 1 | |a Fujieda, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Goto, Hideki |e verfasserin |4 aut | |
| 700 | 1 | |a Hashimoto, Daigo |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuno, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Teshima, Takanori |e verfasserin |4 aut | |
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