An MYC-Driven Vicious Circuit Is a Targetable Achilles' Heel in Lymphoma
©2023 American Association for Cancer Research..
SUMMARY: In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine-hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development. See related article by Nakanishi et al., p. 294 (4).
| Errataetall: |
CommentIn: Blood Cancer Discov. 2023 Jul 5;4(4):294-317. - PMID 37070973 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
Blood cancer discovery - 4(2023), 4 vom: 05. Juli, Seite 248-251 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wilson, Erica B [VerfasserIn] |
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| Links: |
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| Themen: |
3874VXF092 |
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| Anmerkungen: |
Date Completed 06.07.2023 Date Revised 06.01.2024 published: Print CommentIn: Blood Cancer Discov. 2023 Jul 5;4(4):294-317. - PMID 37070973 Citation Status MEDLINE |
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| doi: |
10.1158/2643-3230.BCD-23-0053 |
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| funding: |
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| PPN (Katalog-ID): |
NLM358164494 |
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| 520 | |a SUMMARY: In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine-hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development. See related article by Nakanishi et al., p. 294 (4) | ||
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