Maternal anemia is associated with adverse maternal and neonatal outcomes in Mbarara, Uganda
PURPOSE: Maternal anemia is a significant risk factor for maternal morbidity and mortality, increasing risk of preterm birth, intrauterine growth restriction, stillbirth, and death. Moderate and severe anemia in pregnancy is defined as hemoglobin (Hb) <10 g/dl and Hb < 7 g/dl, respectively. We aimed to characterize the association of maternal anemia with maternal, neonatal, and placental outcomes in a resource-limited setting.
METHODS: Data were collected from a prospective cohort of 352 pregnant women at a tertiary academic Ugandan hospital. One hundred and seventy-six (50%) of women were living with HIV. Hemoglobin was measured in labor, and placentas were collected postpartum. Maternal outcomes included mode of delivery, hemorrhage, blood transfusion, intensive care unit admission, and maternal mortality. Neonatal outcomes included gestational age at delivery, birthweight, stillbirth, and neonatal mortality. Placental descriptors included weight and thickness. Categorical variables were analyzed using Chi-squared and Fisher's exact tests.
RESULTS: Hemoglobin < 10 g/dl, was present in 17/352 (5%) of women. Significantly more women with moderate or severe anemia were HIV-infected: 14/17 (82%) versus 162/335 (48%) (p = .006). Blood transfusions (2/17, 12% versus 5/335, 2%, p = .04) and neonatal deaths (2/17, 12% versus 9/335, 3%, p = .01) were more common in the anemia group. Placental thickness was lower in the anemia group (1.4 cm versus 1.7 cm, p = .04).
CONCLUSIONS: Moderate and severe anemia was associated with maternal HIV infection, maternal blood transfusion, neonatal death, and decreased placental thickness. The overall rate of moderate and severe anemia among this cohort was lower than previously reported.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 36(2023), 1 vom: 10. Dez., Seite 2190834 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Edelson, P Kaitlyn [VerfasserIn] |
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| Links: |
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| Themen: |
Anemia |
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| Anmerkungen: |
Date Completed 15.06.2023 Date Revised 02.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/14767058.2023.2190834 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358142245 |
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| 245 | 1 | 0 | |a Maternal anemia is associated with adverse maternal and neonatal outcomes in Mbarara, Uganda |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Maternal anemia is a significant risk factor for maternal morbidity and mortality, increasing risk of preterm birth, intrauterine growth restriction, stillbirth, and death. Moderate and severe anemia in pregnancy is defined as hemoglobin (Hb) <10 g/dl and Hb < 7 g/dl, respectively. We aimed to characterize the association of maternal anemia with maternal, neonatal, and placental outcomes in a resource-limited setting | ||
| 520 | |a METHODS: Data were collected from a prospective cohort of 352 pregnant women at a tertiary academic Ugandan hospital. One hundred and seventy-six (50%) of women were living with HIV. Hemoglobin was measured in labor, and placentas were collected postpartum. Maternal outcomes included mode of delivery, hemorrhage, blood transfusion, intensive care unit admission, and maternal mortality. Neonatal outcomes included gestational age at delivery, birthweight, stillbirth, and neonatal mortality. Placental descriptors included weight and thickness. Categorical variables were analyzed using Chi-squared and Fisher's exact tests | ||
| 520 | |a RESULTS: Hemoglobin < 10 g/dl, was present in 17/352 (5%) of women. Significantly more women with moderate or severe anemia were HIV-infected: 14/17 (82%) versus 162/335 (48%) (p = .006). Blood transfusions (2/17, 12% versus 5/335, 2%, p = .04) and neonatal deaths (2/17, 12% versus 9/335, 3%, p = .01) were more common in the anemia group. Placental thickness was lower in the anemia group (1.4 cm versus 1.7 cm, p = .04) | ||
| 520 | |a CONCLUSIONS: Moderate and severe anemia was associated with maternal HIV infection, maternal blood transfusion, neonatal death, and decreased placental thickness. The overall rate of moderate and severe anemia among this cohort was lower than previously reported | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anemia | |
| 650 | 4 | |a blood transfusion | |
| 650 | 4 | |a global health | |
| 650 | 4 | |a maternal morbidity | |
| 650 | 4 | |a neonatal morbidity | |
| 650 | 4 | |a placental pathology | |
| 700 | 1 | |a Cao, Danni |e verfasserin |4 aut | |
| 700 | 1 | |a James, Kaitlyn E |e verfasserin |4 aut | |
| 700 | 1 | |a Ngonzi, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Roberts, Drucilla J |e verfasserin |4 aut | |
| 700 | 1 | |a Bebell, Lisa M |e verfasserin |4 aut | |
| 700 | 1 | |a Boatin, Adeline A |e verfasserin |4 aut | |
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