Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism
© 2023 Khloud M. Alquraan et al., published by Sciendo..
INTRODUCTION: Venous thromboembolism (VTE) is the third most common hemostatic disease worldwide. Studies have reported a role for microRNA (miRNA) in the homeostasis and development of VTE. The ras-related nuclear protein (RAN) and exportin 5 (XPO5) genes are involved in miRNA biogenesis, as both regulate the transport of pre-miRNA from the nucleus to the cytoplasm. Therefore, the aim of the current study is to examine the association between RAN (rs14035) and XPO5 (rs11077) single nucleotide polymorphisms (SNPs) and VTE.
METHODS: The study sample consisted of 300 subjects (150 patients and 150 age and sex matched controls). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and tetra-primer amplification refractory mutation system (T-ARMS) techniques were used to genotype rs14035 and rs11077, respectively.
RESULTS: The results showed that there was a significant association between the XPO5 rs11077 and the risk of VTE (P < 0.05). Subjects with AC (OR: 2.08, CI:1.26-3.44) and CC (OR: 1.77, CI: 0.88-3.55) genotypes were at increased risk of the developing VTE. Regarding RAN gene, no association was found between rs14035 and VTE (P > 0.05). In addition, no associations were found between XPO5 rs11077 and RAN rs14035 genotypes with blood cell parameters (P > 0.05). As for the demographic characteristics, the results indicated a strong association between family history and body mass index (BMI) with the risk of VTE (P < 0.01).
CONCLUSION: The XPO5 rs11077, BMI and family history might contribute to the development of VTE in Jordan.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Romanian journal of internal medicine = Revue roumaine de medecine interne - 61(2023), 3 vom: 01. Sept., Seite 154-162 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alquraan, Khloud M [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.6.5.2 |
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| Anmerkungen: |
Date Completed 11.08.2023 Date Revised 11.08.2023 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.2478/rjim-2023-0014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358127831 |
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| 100 | 1 | |a Alquraan, Khloud M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 11.08.2023 | ||
| 500 | |a Date Revised 11.08.2023 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Khloud M. Alquraan et al., published by Sciendo. | ||
| 520 | |a INTRODUCTION: Venous thromboembolism (VTE) is the third most common hemostatic disease worldwide. Studies have reported a role for microRNA (miRNA) in the homeostasis and development of VTE. The ras-related nuclear protein (RAN) and exportin 5 (XPO5) genes are involved in miRNA biogenesis, as both regulate the transport of pre-miRNA from the nucleus to the cytoplasm. Therefore, the aim of the current study is to examine the association between RAN (rs14035) and XPO5 (rs11077) single nucleotide polymorphisms (SNPs) and VTE | ||
| 520 | |a METHODS: The study sample consisted of 300 subjects (150 patients and 150 age and sex matched controls). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and tetra-primer amplification refractory mutation system (T-ARMS) techniques were used to genotype rs14035 and rs11077, respectively | ||
| 520 | |a RESULTS: The results showed that there was a significant association between the XPO5 rs11077 and the risk of VTE (P < 0.05). Subjects with AC (OR: 2.08, CI:1.26-3.44) and CC (OR: 1.77, CI: 0.88-3.55) genotypes were at increased risk of the developing VTE. Regarding RAN gene, no association was found between rs14035 and VTE (P > 0.05). In addition, no associations were found between XPO5 rs11077 and RAN rs14035 genotypes with blood cell parameters (P > 0.05). As for the demographic characteristics, the results indicated a strong association between family history and body mass index (BMI) with the risk of VTE (P < 0.01) | ||
| 520 | |a CONCLUSION: The XPO5 rs11077, BMI and family history might contribute to the development of VTE in Jordan | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Genes | |
| 650 | 4 | |a MicroRNAs | |
| 650 | 4 | |a Risk | |
| 650 | 4 | |a Single nucleotide polymorphism | |
| 650 | 4 | |a Venous Thromboembolism | |
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| 650 | 7 | |a XPO5 protein, human |2 NLM | |
| 650 | 7 | |a RAN protein, human |2 NLM | |
| 700 | 1 | |a Khabour, Omar F |e verfasserin |4 aut | |
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