A single case report of STN-DBS for severe crack-cocaine dependence : double-blind ON vs. SHAM randomized controlled assessment
Copyright © 2023 Vorspan, Domenech, Grabli, Yelnik, Delavest, Dauré, Bellivier, Pelissolo, Belaid, Baunez, Karachi and Mallet..
Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with "ON-DBS" vs. "SHAM-DBS" for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in psychiatry - 14(2023) vom: 07., Seite 1146492 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vorspan, Florence [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Revised 13.06.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fpsyt.2023.1146492 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358061547 |
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| 520 | |a Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with "ON-DBS" vs. "SHAM-DBS" for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a cocaine dependence | |
| 650 | 4 | |a controlled clinical trial | |
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| 700 | 1 | |a Domenech, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Grabli, David |e verfasserin |4 aut | |
| 700 | 1 | |a Yelnik, Jérôme |e verfasserin |4 aut | |
| 700 | 1 | |a Delavest, Marine |e verfasserin |4 aut | |
| 700 | 1 | |a Dauré, Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Bellivier, Frank |e verfasserin |4 aut | |
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| 700 | 1 | |a Belaid, Hayat |e verfasserin |4 aut | |
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| 700 | 1 | |a Mallet, Luc |e verfasserin |4 aut | |
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