Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance
© 2023 Shenyang Pharmaceutical University. Published by Elsevier B.V..
Corrugated surface microparticles comprising levofloxacin (LEV), chitosan and organic acid were prepared using the 3-combo spray drying method. The amount and the boiling point of the organic acid affected the degree of roughness. In this study, we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder inhaler. HMP175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid solution. The ACI and PIV results showed a significant increase in aerodynamic performance of corrugated microparticles. The FPF value of HMP175 L20 was 41.3% ± 3.9% compared with 25.6% ± 7.7% of HMF175 L20. Corrugated microparticles also showed better aerosolization, decreased x-axial velocity, and variable angle. Rapid dissolution of drug formulations was observed in vivo. Low doses administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered orally. Surface modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Asian journal of pharmaceutical sciences - 18(2023), 3 vom: 01. Mai, Seite 100815 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Chang-Soo [VerfasserIn] |
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| Links: |
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| Themen: |
Aerodynamic performance |
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| Anmerkungen: |
Date Revised 13.06.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.ajps.2023.100815 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM358059453 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 Shenyang Pharmaceutical University. Published by Elsevier B.V. | ||
| 520 | |a Corrugated surface microparticles comprising levofloxacin (LEV), chitosan and organic acid were prepared using the 3-combo spray drying method. The amount and the boiling point of the organic acid affected the degree of roughness. In this study, we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder inhaler. HMP175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid solution. The ACI and PIV results showed a significant increase in aerodynamic performance of corrugated microparticles. The FPF value of HMP175 L20 was 41.3% ± 3.9% compared with 25.6% ± 7.7% of HMF175 L20. Corrugated microparticles also showed better aerosolization, decreased x-axial velocity, and variable angle. Rapid dissolution of drug formulations was observed in vivo. Low doses administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered orally. Surface modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aerodynamic performance | |
| 650 | 4 | |a Chitosan | |
| 650 | 4 | |a Corrugated surface | |
| 650 | 4 | |a Levofloxacin | |
| 650 | 4 | |a Organic acid | |
| 700 | 1 | |a Kang, Ji-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Eun Hye |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Hyo-Jung |e verfasserin |4 aut | |
| 700 | 1 | |a Jeong, So-Jeong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Dong-Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Chun-Woong |e verfasserin |4 aut | |
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