Biflavonoid quercetin protects against cyclophosphamide-induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity
Copyright © 2023. Published by Elsevier Ltd..
BACKGROUND: Cyclophosphamide use has been associated with increased oxidative stress in cells and tissues. Quercetin's antioxidative properties make it of potential benefit in such conditions of oxidative stress.
OBJECTIVE: To assess quercetin's ability to mitigate cyclophosphamide-induced organ toxicities in rats.
METHODS: Sixty rats were assigned into six groups. Groups A and D served as normal and cyclophosphamide control and were fed standard rat chow, groups B and E were fed quercetin supplemented diet (100 mg/kg of feed), while those in groups C and F were fed quercetin at 200 mg/kg of feed. Groups A-C received intraperitoneal (ip) normal saline on days 1 and 2, while D-F received ip cyclophosphamide (150 mg/kg/day on days 1 and 2). On day 21, behavioural tests were carried out, animals were sacrificed and blood samples taken. Organs were processed for histological study.
RESULTS: Quercetin reversed cyclophosphamide-induced decrease in body weight, food intake and total antioxidant capacity, and increase in lipid peroxidation (p = 0.001), It also reversed derangement in levels of liver transaminase, urea, creatinine and proinflammatory cytokines (p = 0.001). Improvement in working-memory and anxiety-related behaviours were also observed. Finally, quercetin reversed alterations in levels of acetylcholine, dopamine and brain-derived neurotropic factor (p = 0.021); while reducing serotonin levels and astrocyte immunoreactivity.
CONCLUSION: Quercetin shows significant ability to protect against cyclophosphamide-induced changes in rats.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:178 |
|---|---|
| Enthalten in: |
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 178(2023) vom: 01. Aug., Seite 113879 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Onaolapo, Adejoke Y [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
8N3DW7272P |
|---|
| Anmerkungen: |
Date Completed 31.07.2023 Date Revised 31.07.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.fct.2023.113879 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM358032393 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM358032393 | ||
| 003 | DE-627 | ||
| 005 | 20231226073858.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.fct.2023.113879 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1193.xml |
| 035 | |a (DE-627)NLM358032393 | ||
| 035 | |a (NLM)37301500 | ||
| 035 | |a (PII)S0278-6915(23)00281-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Onaolapo, Adejoke Y |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Biflavonoid quercetin protects against cyclophosphamide-induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.07.2023 | ||
| 500 | |a Date Revised 31.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier Ltd. | ||
| 520 | |a BACKGROUND: Cyclophosphamide use has been associated with increased oxidative stress in cells and tissues. Quercetin's antioxidative properties make it of potential benefit in such conditions of oxidative stress | ||
| 520 | |a OBJECTIVE: To assess quercetin's ability to mitigate cyclophosphamide-induced organ toxicities in rats | ||
| 520 | |a METHODS: Sixty rats were assigned into six groups. Groups A and D served as normal and cyclophosphamide control and were fed standard rat chow, groups B and E were fed quercetin supplemented diet (100 mg/kg of feed), while those in groups C and F were fed quercetin at 200 mg/kg of feed. Groups A-C received intraperitoneal (ip) normal saline on days 1 and 2, while D-F received ip cyclophosphamide (150 mg/kg/day on days 1 and 2). On day 21, behavioural tests were carried out, animals were sacrificed and blood samples taken. Organs were processed for histological study | ||
| 520 | |a RESULTS: Quercetin reversed cyclophosphamide-induced decrease in body weight, food intake and total antioxidant capacity, and increase in lipid peroxidation (p = 0.001), It also reversed derangement in levels of liver transaminase, urea, creatinine and proinflammatory cytokines (p = 0.001). Improvement in working-memory and anxiety-related behaviours were also observed. Finally, quercetin reversed alterations in levels of acetylcholine, dopamine and brain-derived neurotropic factor (p = 0.021); while reducing serotonin levels and astrocyte immunoreactivity | ||
| 520 | |a CONCLUSION: Quercetin shows significant ability to protect against cyclophosphamide-induced changes in rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biflavonoids | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Neurobehaviour | |
| 650 | 7 | |a Quercetin |2 NLM | |
| 650 | 7 | |a 9IKM0I5T1E |2 NLM | |
| 650 | 7 | |a Biflavonoids |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Cyclophosphamide |2 NLM | |
| 650 | 7 | |a 8N3DW7272P |2 NLM | |
| 650 | 7 | |a Neurotransmitter Agents |2 NLM | |
| 700 | 1 | |a Ojo, Foluso O |e verfasserin |4 aut | |
| 700 | 1 | |a Onaolapo, Olakunle J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association |d 1982 |g 178(2023) vom: 01. Aug., Seite 113879 |w (DE-627)NLM012624691 |x 1873-6351 |7 nnns |
| 773 | 1 | 8 | |g volume:178 |g year:2023 |g day:01 |g month:08 |g pages:113879 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.fct.2023.113879 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 178 |j 2023 |b 01 |c 08 |h 113879 | ||