Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features
© 2023 Wiley Periodicals LLC..
BACKGROUND: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features.
METHODS: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled.
RESULTS: The optimal LNR cut-off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228-5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234-8.102; p = 0.016).
CONCLUSION: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Head & neck - 45(2023), 8 vom: 21. Aug., Seite 2017-2027 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tsai, Ming-Hsien [VerfasserIn] |
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| Links: |
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| Themen: |
Extranodal extension |
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| Anmerkungen: |
Date Completed 10.07.2023 Date Revised 16.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/hed.27428 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357982738 |
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| 245 | 1 | 0 | |a Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features |
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| 500 | |a Date Revised 16.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features | ||
| 520 | |a METHODS: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled | ||
| 520 | |a RESULTS: The optimal LNR cut-off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228-5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234-8.102; p = 0.016) | ||
| 520 | |a CONCLUSION: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a extranodal extension | |
| 650 | 4 | |a head and neck squamous cell carcinoma | |
| 650 | 4 | |a lymph node ratio | |
| 650 | 4 | |a lymphovascular invasion | |
| 650 | 4 | |a perineural invasion | |
| 700 | 1 | |a Chuang, Hui-Ching |e verfasserin |4 aut | |
| 700 | 1 | |a Chien, Chih-Yen |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Tai-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Yan-Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Chao-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Chi-Chih |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Wen-Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yu-Tsai |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Fu-Min |e verfasserin |4 aut | |
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