The first reported case of double trisomy 10 and 20 in a product of conception
© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: Double trisomies are rare findings among products of conception and are often lethal to the developing embryo or fetus.
METHODS: Here we describe a double trisomy case with symptoms of threatened miscarriage at 9 weeks gestation. Ultrasound revealed an anembryonic pregnancy. Pregnancy was terminated by dilation and curettage at gestational age 11 weeks and 6 days. Histologic examination and chromosome microarray were performed on a formalin-fixed product of conception (POC) sample to identify the cause of the anembryonic pregnancy.
RESULTS: Chromosome microarray analysis revealed a female chromosome complement with double trisomies 10 and 20, arr(10,20)x3, consistent with a karyotype of 48,XX,+10,+20.
CONCLUSION: To the best of our knowledge, this is the first reported case of double trisomy 10 and 20 in a POC. Due to nonspecific histopathological findings, chromosomal microarray is a powerful tool in identifying and differentiating chromosomal aneuploidies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
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| Enthalten in: |
Laboratory medicine - 55(2024), 2 vom: 07. März, Seite 245-248 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fernandez De La Vega, Joshua [VerfasserIn] |
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| Links: |
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| Themen: |
Chromosome microarray |
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| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/labmed/lmad052 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM357966902 |
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| 245 | 1 | 4 | |a The first reported case of double trisomy 10 and 20 in a product of conception |
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| 500 | |a Date Revised 11.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Double trisomies are rare findings among products of conception and are often lethal to the developing embryo or fetus | ||
| 520 | |a METHODS: Here we describe a double trisomy case with symptoms of threatened miscarriage at 9 weeks gestation. Ultrasound revealed an anembryonic pregnancy. Pregnancy was terminated by dilation and curettage at gestational age 11 weeks and 6 days. Histologic examination and chromosome microarray were performed on a formalin-fixed product of conception (POC) sample to identify the cause of the anembryonic pregnancy | ||
| 520 | |a RESULTS: Chromosome microarray analysis revealed a female chromosome complement with double trisomies 10 and 20, arr(10,20)x3, consistent with a karyotype of 48,XX,+10,+20 | ||
| 520 | |a CONCLUSION: To the best of our knowledge, this is the first reported case of double trisomy 10 and 20 in a POC. Due to nonspecific histopathological findings, chromosomal microarray is a powerful tool in identifying and differentiating chromosomal aneuploidies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a chromosome microarray | |
| 650 | 4 | |a double trisomy 10 and 20 | |
| 650 | 4 | |a genetics | |
| 650 | 4 | |a laboratory genetics and genomics | |
| 650 | 4 | |a product of conception | |
| 650 | 4 | |a triplosensitivity | |
| 700 | 1 | |a Lahiji, Arian Pourmehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Raymond, Caitlin |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Song |e verfasserin |4 aut | |
| 700 | 1 | |a Thaker, Harshwardhan |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Jianli |e verfasserin |4 aut | |
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