Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
Copyright © 2023 Dugardin, Demar, Hafsi, Amroun, Aurelus, Drak Alsibai, Ntoutoum, Santa, Nacher and Sabbah..
Background: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy-tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused on the role of HTLV-1. We aimed to investigate the association between HTLV-1 and biological thyroid dysfunction.
Methods: We included 357 patients with a positive HTLV-1 serology and thyroid-stimulating hormone assay data between 2012 and 2021 in a hospital in French Guiana; we compared the prevalence of hypothyroidism and hyperthyroidism in this group with that in an HTLV-1-negative control group (722 persons) matched for sex and age.
Results: The prevalence of hypothyroidism and hyperthyroidism in patients with HTLV-1 infection was significantly higher than that in the control group (11% versus 3.2% and 11.3% versus 2.3%, respectively; p < 0.001).
Conclusion: Our study shows, for the first time, the association between HTLV-1 and dysthyroidism in a large sample, suggesting that thyroid function exploration should be systematically implemented in this population as this may have an impact on therapeutic management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Frontiers in cellular and infection microbiology - 13(2023) vom: 16., Seite 1164526 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dugardin, Julia [VerfasserIn] |
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| Links: |
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| Themen: |
French Guiana |
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| Anmerkungen: |
Date Completed 24.11.2023 Date Revised 21.02.2024 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fcimb.2023.1164526 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357949811 |
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| 500 | |a Date Revised 21.02.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Dugardin, Demar, Hafsi, Amroun, Aurelus, Drak Alsibai, Ntoutoum, Santa, Nacher and Sabbah. | ||
| 520 | |a Background: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy-tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused on the role of HTLV-1. We aimed to investigate the association between HTLV-1 and biological thyroid dysfunction | ||
| 520 | |a Methods: We included 357 patients with a positive HTLV-1 serology and thyroid-stimulating hormone assay data between 2012 and 2021 in a hospital in French Guiana; we compared the prevalence of hypothyroidism and hyperthyroidism in this group with that in an HTLV-1-negative control group (722 persons) matched for sex and age | ||
| 520 | |a Results: The prevalence of hypothyroidism and hyperthyroidism in patients with HTLV-1 infection was significantly higher than that in the control group (11% versus 3.2% and 11.3% versus 2.3%, respectively; p < 0.001) | ||
| 520 | |a Conclusion: Our study shows, for the first time, the association between HTLV-1 and dysthyroidism in a large sample, suggesting that thyroid function exploration should be systematically implemented in this population as this may have an impact on therapeutic management | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a French Guiana | |
| 650 | 4 | |a HTLV- 1 | |
| 650 | 4 | |a TSH (thyroid stimulating hormone) | |
| 650 | 4 | |a hyperthyroidism | |
| 650 | 4 | |a hypothyroidism | |
| 650 | 4 | |a thyroiditis | |
| 700 | 1 | |a Demar, Magalie |e verfasserin |4 aut | |
| 700 | 1 | |a Hafsi, Nezha |e verfasserin |4 aut | |
| 700 | 1 | |a Amroun, Hakim |e verfasserin |4 aut | |
| 700 | 1 | |a Aurelus, Jean-Markens |e verfasserin |4 aut | |
| 700 | 1 | |a Drak Alsibai, Kinan |e verfasserin |4 aut | |
| 700 | 1 | |a Ntoutoum, André |e verfasserin |4 aut | |
| 700 | 1 | |a Santa, Florin |e verfasserin |4 aut | |
| 700 | 1 | |a Nacher, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Sabbah, Nadia |e verfasserin |4 aut | |
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