Do vaccinations influence the development of Alzheimer disease?
A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizations against infectious pathogens on the risk of AD; explores the basic and pharmacoepidemiologic evidence for this association, with particular attention paid to important methodological variations among the epidemiologic studies; and reviews the remaining uncertainties regarding the effects of anti-pathogen vaccines on Alzheimer disease and all-cause dementia, with recommendations for future directions to address those uncertainties.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Human vaccines & immunotherapeutics - 19(2023), 2 vom: 01. Aug., Seite 2216625 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bukhbinder, Avram S [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.07.2023 Date Revised 16.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/21645515.2023.2216625 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357929098 |
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| 520 | |a A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizations against infectious pathogens on the risk of AD; explores the basic and pharmacoepidemiologic evidence for this association, with particular attention paid to important methodological variations among the epidemiologic studies; and reviews the remaining uncertainties regarding the effects of anti-pathogen vaccines on Alzheimer disease and all-cause dementia, with recommendations for future directions to address those uncertainties | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer disease | |
| 650 | 4 | |a Vaccines | |
| 650 | 4 | |a dementia | |
| 650 | 4 | |a diphtheria-tetanus-acellular pertussis vaccines | |
| 650 | 4 | |a influenza vaccines | |
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| 650 | 4 | |a pharmacoepidemiology | |
| 650 | 4 | |a pneumococcal vaccines | |
| 650 | 4 | |a trained immunity | |
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| 700 | 1 | |a Harris, Kristofer |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Xiaoqian |e verfasserin |4 aut | |
| 700 | 1 | |a Schulz, Paul E |e verfasserin |4 aut | |
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