Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp
Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (1, 2, 4-8), along with known polyketides (3, 9-13). Structures of compounds 1, 2, and 4-8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum.
| Errataetall: |
ErratumIn: J Nat Prod. 2023 Jul 28;86(7):1884. - PMID 37390505 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
Journal of natural products - 86(2023), 6 vom: 23. Juni, Seite 1476-1486 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Amorim, Marcelo R [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 26.06.2023 Date Revised 12.01.2024 published: Print-Electronic ErratumIn: J Nat Prod. 2023 Jul 28;86(7):1884. - PMID 37390505 Citation Status MEDLINE |
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| doi: |
10.1021/acs.jnatprod.3c00175 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM357916506 |
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| 500 | |a ErratumIn: J Nat Prod. 2023 Jul 28;86(7):1884. - PMID 37390505 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (1, 2, 4-8), along with known polyketides (3, 9-13). Structures of compounds 1, 2, and 4-8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum | ||
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| 700 | 1 | |a Paz, Tiago A |e verfasserin |4 aut | |
| 700 | 1 | |a Ióca, Laura P |e verfasserin |4 aut | |
| 700 | 1 | |a Nicácio, Karen J |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Lucianne F P |e verfasserin |4 aut | |
| 700 | 1 | |a Goulart, Mirian O |e verfasserin |4 aut | |
| 700 | 1 | |a Paulino, Julia M |e verfasserin |4 aut | |
| 700 | 1 | |a da Cruz, Mateus O |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Antonio G |e verfasserin |4 aut | |
| 700 | 1 | |a Furlan, Maysa |e verfasserin |4 aut | |
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| 700 | 1 | |a Dos Santos, Raquel A |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, André |e verfasserin |4 aut | |
| 700 | 1 | |a Guido, Rafael V C |e verfasserin |4 aut | |
| 700 | 1 | |a Berlinck, Roberto G S |e verfasserin |4 aut | |
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