Neurodegeneration in the retina of motoneuron diseases : a longitudinal study in amyotrophic lateral sclerosis and Kennedy's disease
© 2023. The Author(s)..
BACKGROUND: To what extent retinal atrophy in neurodegenerative diseases reflects the severity and/or the chronicity of brain pathology or is a local independent phenomenon remains to be clarified. Moreover, whether retinal atrophy has a clinical (diagnostic and prognostic) value in these diseases remains unclear.
OBJECTIVE: To add light on the pathological significance and clinical value of retinal atrophy in patients with amyotrophic lateral sclerosis (ALS) and Kennedy's disease (KD).
METHODS: Thirty-five ALS, thirty-seven KD, and forty-nine age-matched healthy controls (HC) were included in a one-year longitudinal study. Spectrum-domain optical coherence tomography (OCT) was performed at study entry (T0) and after 12 months (T1). Disease duration and functional rating scale (FRS) for ALS and KD patients were correlated to retinal thicknesses.
RESULTS: Compared to HC, peripapillary retinal nerve fiber layer (pRNFL) thickness was significantly thinner in both ALS (p = 0.034) and KD (p = 0.003). pRNFL was thinner in KD compared to ALS, but the difference was not significant. In KD, pRNFL atrophy significantly correlated with both disease severity (r = 0.296, p = 0.035) and disease duration (r = - 0.308, p = 0.013) while no significant correlation was found in ALS (disease severity: r = 0.147, p = 0.238; disease duration: r = - 0.093, p = 0.459). During the follow-up, pRNFL thickness remained stable in KD while significantly decreased in ALS (p = 0.043).
CONCLUSIONS: Our study provides evidence of retinal atrophy in both ALS and KD and suggests that retinal thinning is a primary local phenomenon in motoneuron diseases. The clinical value of pRNFL atrophy in KD is worthy of further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:270 |
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| Enthalten in: |
Journal of neurology - 270(2023), 9 vom: 29. Sept., Seite 4478-4486 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Miscioscia, Alessandro [VerfasserIn] |
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| Links: |
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| Themen: |
Amyotrophic lateral sclerosis |
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| Anmerkungen: |
Date Completed 14.08.2023 Date Revised 27.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00415-023-11802-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357911423 |
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| 100 | 1 | |a Miscioscia, Alessandro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neurodegeneration in the retina of motoneuron diseases |b a longitudinal study in amyotrophic lateral sclerosis and Kennedy's disease |
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| 500 | |a Date Revised 27.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: To what extent retinal atrophy in neurodegenerative diseases reflects the severity and/or the chronicity of brain pathology or is a local independent phenomenon remains to be clarified. Moreover, whether retinal atrophy has a clinical (diagnostic and prognostic) value in these diseases remains unclear | ||
| 520 | |a OBJECTIVE: To add light on the pathological significance and clinical value of retinal atrophy in patients with amyotrophic lateral sclerosis (ALS) and Kennedy's disease (KD) | ||
| 520 | |a METHODS: Thirty-five ALS, thirty-seven KD, and forty-nine age-matched healthy controls (HC) were included in a one-year longitudinal study. Spectrum-domain optical coherence tomography (OCT) was performed at study entry (T0) and after 12 months (T1). Disease duration and functional rating scale (FRS) for ALS and KD patients were correlated to retinal thicknesses | ||
| 520 | |a RESULTS: Compared to HC, peripapillary retinal nerve fiber layer (pRNFL) thickness was significantly thinner in both ALS (p = 0.034) and KD (p = 0.003). pRNFL was thinner in KD compared to ALS, but the difference was not significant. In KD, pRNFL atrophy significantly correlated with both disease severity (r = 0.296, p = 0.035) and disease duration (r = - 0.308, p = 0.013) while no significant correlation was found in ALS (disease severity: r = 0.147, p = 0.238; disease duration: r = - 0.093, p = 0.459). During the follow-up, pRNFL thickness remained stable in KD while significantly decreased in ALS (p = 0.043) | ||
| 520 | |a CONCLUSIONS: Our study provides evidence of retinal atrophy in both ALS and KD and suggests that retinal thinning is a primary local phenomenon in motoneuron diseases. The clinical value of pRNFL atrophy in KD is worthy of further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Amyotrophic lateral sclerosis | |
| 650 | 4 | |a Biomarker | |
| 650 | 4 | |a Kennedy’s disease | |
| 650 | 4 | |a Motoneuron disease | |
| 650 | 4 | |a Neurodegeneration | |
| 650 | 4 | |a Optical coherence tomography | |
| 700 | 1 | |a Puthenparampil, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Blasi, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Rinaldi, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Perini, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Sorarù, Gianni |e verfasserin |4 aut | |
| 700 | 1 | |a Gallo, Paolo |e verfasserin |4 aut | |
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