Sarcopenia as a Prognostic Factor in Patients with Hepatoblastoma : Does It Influence Surgical Outcomes and Survival? Preliminary Retrospective Study
Copyright © 2023 Elsevier Inc. All rights reserved..
AIM: Sarcopenia is associated with poor prognosis in adult oncologic patients, with little evidence of this association in pediatric population, including hepatoblastoma.
METHODS: Retrospective study in patients with hepatoblastoma, divided into those with or without sarcopenia. Sarcopenia was assessed by measuring psoas muscle area (PMA) at L4-L5 level on the CT/MR and defined as z-score values ≤ 2. Relapse and mortality were analyzed.
RESULTS: Twenty-one patients (57.1% male) were included, with median age 35.7 months (IQR: 23.5-58.5). Seven (33.3%) had sarcopenia on initial studies compared to 14 (66.7%) who did not. No differences were found between groups in age, weight, PRETEXT, surgical treatment or. α-fetoprotein levels. Sarcopenia was associated with a higher rate of metastases at diagnosis (49.2% vs 0.0%; p = 0.026) and surgical complications (57.1% vs 21.4%, p = 0.047). After a median follow-up of 65.1 months (1.7-144.8), 2 patients (28.6%) had tumor relapse in sarcopenic group compared to 1 (7.1%) in non-sarcopenic group. Two patients died in sarcopenic group and 1 in non-sarcopenic group. Median event-free survival (EFS) was lower in sarcopenic group (100.38 ± 25.63 vs 118.91 ± 11.52 months) as well as overall survival (OS) (101.72 ± 24.86 vs 121.78 ± 8.75 months) with no statistical significance. Five-year EFS was also lower in sarcopenic group (71% vs 93%) as well as 5-year OS (71% vs 87%).
CONCLUSIONS: Sarcopenia at diagnosis was associated with a higher rate of metastases and surgical complications in hepatoblastoma. Our data shows the first evidence of its role as a possible poor prognostic factor, influencing survival and risk of relapse.
LEVEL OF EVIDENCE: II.
TYPE OF STUDY: Original article. Retrospective study.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Journal of pediatric surgery - 58(2023), 11 vom: 29. Nov., Seite 2149-2155 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Muñoz-Serrano, Antonio Jesús [VerfasserIn] |
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| Links: |
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| Themen: |
Children |
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| Anmerkungen: |
Date Revised 20.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jpedsurg.2023.05.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357882563 |
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| 100 | 1 | |a Muñoz-Serrano, Antonio Jesús |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sarcopenia as a Prognostic Factor in Patients with Hepatoblastoma |b Does It Influence Surgical Outcomes and Survival? Preliminary Retrospective Study |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a AIM: Sarcopenia is associated with poor prognosis in adult oncologic patients, with little evidence of this association in pediatric population, including hepatoblastoma | ||
| 520 | |a METHODS: Retrospective study in patients with hepatoblastoma, divided into those with or without sarcopenia. Sarcopenia was assessed by measuring psoas muscle area (PMA) at L4-L5 level on the CT/MR and defined as z-score values ≤ 2. Relapse and mortality were analyzed | ||
| 520 | |a RESULTS: Twenty-one patients (57.1% male) were included, with median age 35.7 months (IQR: 23.5-58.5). Seven (33.3%) had sarcopenia on initial studies compared to 14 (66.7%) who did not. No differences were found between groups in age, weight, PRETEXT, surgical treatment or. α-fetoprotein levels. Sarcopenia was associated with a higher rate of metastases at diagnosis (49.2% vs 0.0%; p = 0.026) and surgical complications (57.1% vs 21.4%, p = 0.047). After a median follow-up of 65.1 months (1.7-144.8), 2 patients (28.6%) had tumor relapse in sarcopenic group compared to 1 (7.1%) in non-sarcopenic group. Two patients died in sarcopenic group and 1 in non-sarcopenic group. Median event-free survival (EFS) was lower in sarcopenic group (100.38 ± 25.63 vs 118.91 ± 11.52 months) as well as overall survival (OS) (101.72 ± 24.86 vs 121.78 ± 8.75 months) with no statistical significance. Five-year EFS was also lower in sarcopenic group (71% vs 93%) as well as 5-year OS (71% vs 87%) | ||
| 520 | |a CONCLUSIONS: Sarcopenia at diagnosis was associated with a higher rate of metastases and surgical complications in hepatoblastoma. Our data shows the first evidence of its role as a possible poor prognostic factor, influencing survival and risk of relapse | ||
| 520 | |a LEVEL OF EVIDENCE: II | ||
| 520 | |a TYPE OF STUDY: Original article. Retrospective study | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Hepatoblastoma | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a Sarcopenia | |
| 650 | 4 | |a Surgery | |
| 700 | 1 | |a Estefanía-Fernández, Karla |e verfasserin |4 aut | |
| 700 | 1 | |a Oterino, César |e verfasserin |4 aut | |
| 700 | 1 | |a Ramírez-Amoros, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Navarro, Gema |e verfasserin |4 aut | |
| 700 | 1 | |a Sastre, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Martínez, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Barrena, Sátur |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveros, Francisco Hernández |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, Leopoldo |e verfasserin |4 aut | |
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