Artemisinin-based combination therapy successfully treated two hyperparasitaemic Plasmodium falciparum cases
Copyright (c) 2023 Benudhar Mukhi, Himanshu Gupta, Kishore Punnath, Anupkumar R Anvikar, Bina Srivastava, Susanta Kumar Ghosh..
Hyperparasitaemia is an important event in the cascade of Plasmodium falciparum severe malaria (SM), and may also lead to SM associated complications and death, if left untreated. Here, we report two hyperparasitaemic patients with no life-threatening complications. Malaria diagnosis was performed using thick and thin blood smears and immunochromatographic-based rapid diagnostic tests (RDTs) purchased from three different manufacturers. Parasitaemia was calculated following the World Health Organization (WHO) guidelines. Haematological and biochemical investigations were also performed. Weekly follow-up of blood smear examination, blood pressure and temperature were recorded up to day 63. The first patient had 42% parasitaemia (100% asexual parasites). The second patient had 9.5% parasitaemia, comprising 46% asexual and 54% sexual stages, with a 1:1 male to female ratio. On the day of admission, both had presented abnormal haematological and biochemical parameters compared to the reference values. Remarkably, both the patients recovered successfully with oral artemisinin-based combination therapy (ACT) and a single dose of primaquine on day 1. Weekly follow-up did not show any parasite suggesting successful treatment with ACT without any side effects. The presence of hypergametocytaemia may hinder malaria elimination efforts, if not treated immediately.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Journal of infection in developing countries - 17(2023), 5 vom: 31. Mai, Seite 725-731 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mukhi, Benudhar [VerfasserIn] |
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| Links: |
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| Themen: |
ACT |
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| Anmerkungen: |
Date Completed 08.06.2023 Date Revised 15.06.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3855/jidc.17652 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357813146 |
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| 520 | |a Copyright (c) 2023 Benudhar Mukhi, Himanshu Gupta, Kishore Punnath, Anupkumar R Anvikar, Bina Srivastava, Susanta Kumar Ghosh. | ||
| 520 | |a Hyperparasitaemia is an important event in the cascade of Plasmodium falciparum severe malaria (SM), and may also lead to SM associated complications and death, if left untreated. Here, we report two hyperparasitaemic patients with no life-threatening complications. Malaria diagnosis was performed using thick and thin blood smears and immunochromatographic-based rapid diagnostic tests (RDTs) purchased from three different manufacturers. Parasitaemia was calculated following the World Health Organization (WHO) guidelines. Haematological and biochemical investigations were also performed. Weekly follow-up of blood smear examination, blood pressure and temperature were recorded up to day 63. The first patient had 42% parasitaemia (100% asexual parasites). The second patient had 9.5% parasitaemia, comprising 46% asexual and 54% sexual stages, with a 1:1 male to female ratio. On the day of admission, both had presented abnormal haematological and biochemical parameters compared to the reference values. Remarkably, both the patients recovered successfully with oral artemisinin-based combination therapy (ACT) and a single dose of primaquine on day 1. Weekly follow-up did not show any parasite suggesting successful treatment with ACT without any side effects. The presence of hypergametocytaemia may hinder malaria elimination efforts, if not treated immediately | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a ACT | |
| 650 | 4 | |a Plasmodium falciparum | |
| 650 | 4 | |a hypergametocytaemia | |
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| 650 | 4 | |a primaquine | |
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| 700 | 1 | |a Srivastava, Bina |e verfasserin |4 aut | |
| 700 | 1 | |a Ghosh, Susanta Kumar |e verfasserin |4 aut | |
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