Impact of partial pressure of arterial oxygen and radiologic findings on postoperative acute exacerbation of idiopathic interstitial pneumonia in patients with lung cancer
© 2023. The Author(s)..
PURPOSE: To establish accurate diagnostic criteria and predictors of treatment response for postoperative acute exacerbation (AE) in patients with lung cancer and idiopathic interstitial pneumonia (IIP).
METHODS: Among 93 patients with IIP who underwent surgery for lung cancer, suspected postoperative AE developed in 20 (21.5%). Patients were divided into a progressive AE group, comprising patients with bilateral alveolar opacities and decreasing PaO2 ≥ 10 mmHg (n = 5); an incipient AE group, comprising patients with unilateral alveolar opacities and decreasing PaO2 ≥ 10 mmHg (n = 10); and an indeterminate AE group, comprising patients with alveolar opacities but decreasing PaO2 < 10 mmHg (n = 5).
RESULTS: The progressive AE group had significantly higher 90-day mortality (80%) than the incipient AE group (10%, P = 0.017) or the indeterminate AE group (0%, P = 0.048). Bilateral opacities may indicate advanced AE and poor prognosis, whereas unilateral opacities may indicate an early stage of AE and a good prognosis. PaO2 < 10 mmHg may indicate conditions other than AE.
CONCLUSIONS: In patients with lung cancer and IIP, decreasing PaO2 and HRCT findings may allow for the initiation of rapid and accurate treatment strategies for postoperative AE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Surgery today - 54(2024), 2 vom: 28. Jan., Seite 122-129 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Azuma, Yoko [VerfasserIn] |
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| Links: |
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| Themen: |
Idiopathic interstitial lung disease |
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| Anmerkungen: |
Date Completed 23.01.2024 Date Revised 25.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00595-023-02711-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM35780791X |
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| 100 | 1 | |a Azuma, Yoko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of partial pressure of arterial oxygen and radiologic findings on postoperative acute exacerbation of idiopathic interstitial pneumonia in patients with lung cancer |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 23.01.2024 | ||
| 500 | |a Date Revised 25.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: To establish accurate diagnostic criteria and predictors of treatment response for postoperative acute exacerbation (AE) in patients with lung cancer and idiopathic interstitial pneumonia (IIP) | ||
| 520 | |a METHODS: Among 93 patients with IIP who underwent surgery for lung cancer, suspected postoperative AE developed in 20 (21.5%). Patients were divided into a progressive AE group, comprising patients with bilateral alveolar opacities and decreasing PaO2 ≥ 10 mmHg (n = 5); an incipient AE group, comprising patients with unilateral alveolar opacities and decreasing PaO2 ≥ 10 mmHg (n = 10); and an indeterminate AE group, comprising patients with alveolar opacities but decreasing PaO2 < 10 mmHg (n = 5) | ||
| 520 | |a RESULTS: The progressive AE group had significantly higher 90-day mortality (80%) than the incipient AE group (10%, P = 0.017) or the indeterminate AE group (0%, P = 0.048). Bilateral opacities may indicate advanced AE and poor prognosis, whereas unilateral opacities may indicate an early stage of AE and a good prognosis. PaO2 < 10 mmHg may indicate conditions other than AE | ||
| 520 | |a CONCLUSIONS: In patients with lung cancer and IIP, decreasing PaO2 and HRCT findings may allow for the initiation of rapid and accurate treatment strategies for postoperative AE | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Idiopathic interstitial lung disease | |
| 650 | 4 | |a Lung cancer | |
| 650 | 4 | |a Postoperative acute exacerbation | |
| 650 | 7 | |a Oxygen |2 NLM | |
| 650 | 7 | |a S88TT14065 |2 NLM | |
| 700 | 1 | |a Sakamoto, Susumu |e verfasserin |4 aut | |
| 700 | 1 | |a Homma, Sakae |e verfasserin |4 aut | |
| 700 | 1 | |a Sakai, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Koezuka, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Kamemura, Megumi |e verfasserin |4 aut | |
| 700 | 1 | |a Tochigi, Naobumi |e verfasserin |4 aut | |
| 700 | 1 | |a Iyoda, Akira |e verfasserin |4 aut | |
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