Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
PURPOSE: Verify the association between anticholinergic burden and health-related quality of life of patients with multiple myeloma.
METHODS: Cross-sectional study with multiple myeloma outpatient from a state capital city in southeastern Brazil. Sociodemographic, clinical, and pharmacotherapeutic variables were collected by interview. Clinical data were complemented by medical records. Drugs with anticholinergic activity were identified with Brazilian Anticholinergic Activity Drug Scale. Health-related quality of life scores were obtained using QLQ-C30 and QLQ-MY20 instruments. Mann-Whitney was used to compare the median of the health-related quality of life scale scores and the independent variables. Multivariate linear regression was performed to verify the association between independent variables and health-related quality of life scores.
RESULTS: Two hundred thirteen patients were included, 56.3% had multi-morbidities, and 71.8% used polypharmacy. In all health-related quality of life domains, there were differences between the medians of the polypharmacy variable. A significant difference was identified between the ACh burden and QLQ-C30 and QLQ-MY20 scores. Linear regression identified an association between the use of drugs with anticholinergic activity and the reduction of global status scores (QLQ-C30), functional scale (QLQ-C30), body image (QLQ-MY20), and future perspective (QLQ-MY20). Drugs with anticholinergic activity were associated with increased symptom scores (QLQ-C30 and QLQ-MY20). Polypharmacy was associated with reduction of functioning score and increase of symptom score (QLQ-C30).
CONCLUSION: Anticholinergic burden in MM patients is associated with lower scores in quality of life domains: global health and symptoms (QLQ-C30) and functional (QLQ-C30 and QLQ-MY20). The presence of polypharmacy is also associated with lower scores for functional scales and symptom scales (QLQ-C30).
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
---|---|
Enthalten in: |
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 31(2023), 7 vom: 06. Juni, Seite 379 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
de Lima, Mariana Sampaio Rodrigues [VerfasserIn] |
---|
Links: |
---|
Themen: |
Adult |
---|
Anmerkungen: |
Date Completed 08.06.2023 Date Revised 08.06.2023 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00520-023-07835-y |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM357806506 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM357806506 | ||
003 | DE-627 | ||
005 | 20231226073404.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00520-023-07835-y |2 doi | |
028 | 5 | 2 | |a pubmed24n1192.xml |
035 | |a (DE-627)NLM357806506 | ||
035 | |a (NLM)37278732 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a de Lima, Mariana Sampaio Rodrigues |e verfasserin |4 aut | |
245 | 1 | 0 | |a Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 08.06.2023 | ||
500 | |a Date Revised 08.06.2023 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
520 | |a PURPOSE: Verify the association between anticholinergic burden and health-related quality of life of patients with multiple myeloma | ||
520 | |a METHODS: Cross-sectional study with multiple myeloma outpatient from a state capital city in southeastern Brazil. Sociodemographic, clinical, and pharmacotherapeutic variables were collected by interview. Clinical data were complemented by medical records. Drugs with anticholinergic activity were identified with Brazilian Anticholinergic Activity Drug Scale. Health-related quality of life scores were obtained using QLQ-C30 and QLQ-MY20 instruments. Mann-Whitney was used to compare the median of the health-related quality of life scale scores and the independent variables. Multivariate linear regression was performed to verify the association between independent variables and health-related quality of life scores | ||
520 | |a RESULTS: Two hundred thirteen patients were included, 56.3% had multi-morbidities, and 71.8% used polypharmacy. In all health-related quality of life domains, there were differences between the medians of the polypharmacy variable. A significant difference was identified between the ACh burden and QLQ-C30 and QLQ-MY20 scores. Linear regression identified an association between the use of drugs with anticholinergic activity and the reduction of global status scores (QLQ-C30), functional scale (QLQ-C30), body image (QLQ-MY20), and future perspective (QLQ-MY20). Drugs with anticholinergic activity were associated with increased symptom scores (QLQ-C30 and QLQ-MY20). Polypharmacy was associated with reduction of functioning score and increase of symptom score (QLQ-C30) | ||
520 | |a CONCLUSION: Anticholinergic burden in MM patients is associated with lower scores in quality of life domains: global health and symptoms (QLQ-C30) and functional (QLQ-C30 and QLQ-MY20). The presence of polypharmacy is also associated with lower scores for functional scales and symptom scales (QLQ-C30) | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Adult | |
650 | 4 | |a Aged | |
650 | 4 | |a Cholinergic antagonists | |
650 | 4 | |a Health-related quality of life | |
650 | 4 | |a Multiple myeloma | |
700 | 1 | |a de Pádua, Cristiane Aparecida Menezes |e verfasserin |4 aut | |
700 | 1 | |a de Miranda Drummond, Paula Lana |e verfasserin |4 aut | |
700 | 1 | |a Silveira, Lívia Pena |e verfasserin |4 aut | |
700 | 1 | |a Malta, Jéssica Soares |e verfasserin |4 aut | |
700 | 1 | |a Dos Santos, Roberta Márcia Marques |e verfasserin |4 aut | |
700 | 1 | |a Reis, Adriano Max Moreira |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer |d 1994 |g 31(2023), 7 vom: 06. Juni, Seite 379 |w (DE-627)NLM07487618X |x 1433-7339 |7 nnns |
773 | 1 | 8 | |g volume:31 |g year:2023 |g number:7 |g day:06 |g month:06 |g pages:379 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00520-023-07835-y |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 31 |j 2023 |e 7 |b 06 |c 06 |h 379 |