Rehabilitation Outcomes in Children With Acute Flaccid Myelitis From 2014 to 2019 : A Multicenter Retrospective Review
Copyright © 2023 Elsevier Inc. All rights reserved..
BACKGROUND: Acute flaccid myelitis (AFM) is a childhood illness characterized by sudden-onset weakness impairing function. The primary goal was to compare the motor recovery patterns of patients with AFM who were discharged home or to inpatient rehabilitation. Secondary analyses focused on recovery of respiratory status, nutritional status, and neurogenic bowel and bladder in both cohorts.
METHODS: Eleven tertiary care centers in the United States performed a retrospective chart review of children with AFM between January 1, 2014, and October 1, 2019. Data included demographics, treatments, and outcomes on admission, discharge, and follow-up visits.
RESULTS: Medical records of 109 children met inclusion criteria; 67 children required inpatient rehabilitation, whereas 42 children were discharged directly home. The median age was 5 years (range 4 months to 17 years), and the median time observed was 417 days (interquartile range = 645 days). Distal upper extremities recovered better than the proximal upper extremities. At acute presentation, children who needed inpatient rehabilitation had significantly higher rates of respiratory support (P < 0.001), nutritional support (P < 0.001), and neurogenic bowel (P = 0.004) and bladder (P = 0.002). At follow-up, those who attended inpatient rehabilitation continued to have higher rates of respiratory support (28% vs 12%, P = 0.043); however, the nutritional status and bowel/bladder function were no longer statistically different.
CONCLUSIONS: All children made improvements in strength. Proximal muscles remained weaker than distal muscles in the upper extremities. Children who qualified for inpatient rehabilitation had ongoing respiratory needs at follow-up; however, recovery of nutritional status and bowel/bladder were similar.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:145 |
|---|---|
| Enthalten in: |
Pediatric neurology - 145(2023) vom: 30. Aug., Seite 41-47 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Marchese, Diana L [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute flaccid myelitis (AFM) |
|---|
| Anmerkungen: |
Date Completed 10.07.2023 Date Revised 16.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.pediatrneurol.2023.04.027 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM357730844 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM357730844 | ||
| 003 | DE-627 | ||
| 005 | 20231226073226.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pediatrneurol.2023.04.027 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1192.xml |
| 035 | |a (DE-627)NLM357730844 | ||
| 035 | |a (NLM)37271056 | ||
| 035 | |a (PII)S0887-8994(23)00143-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Marchese, Diana L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Rehabilitation Outcomes in Children With Acute Flaccid Myelitis From 2014 to 2019 |b A Multicenter Retrospective Review |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 10.07.2023 | ||
| 500 | |a Date Revised 16.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Acute flaccid myelitis (AFM) is a childhood illness characterized by sudden-onset weakness impairing function. The primary goal was to compare the motor recovery patterns of patients with AFM who were discharged home or to inpatient rehabilitation. Secondary analyses focused on recovery of respiratory status, nutritional status, and neurogenic bowel and bladder in both cohorts | ||
| 520 | |a METHODS: Eleven tertiary care centers in the United States performed a retrospective chart review of children with AFM between January 1, 2014, and October 1, 2019. Data included demographics, treatments, and outcomes on admission, discharge, and follow-up visits | ||
| 520 | |a RESULTS: Medical records of 109 children met inclusion criteria; 67 children required inpatient rehabilitation, whereas 42 children were discharged directly home. The median age was 5 years (range 4 months to 17 years), and the median time observed was 417 days (interquartile range = 645 days). Distal upper extremities recovered better than the proximal upper extremities. At acute presentation, children who needed inpatient rehabilitation had significantly higher rates of respiratory support (P < 0.001), nutritional support (P < 0.001), and neurogenic bowel (P = 0.004) and bladder (P = 0.002). At follow-up, those who attended inpatient rehabilitation continued to have higher rates of respiratory support (28% vs 12%, P = 0.043); however, the nutritional status and bowel/bladder function were no longer statistically different | ||
| 520 | |a CONCLUSIONS: All children made improvements in strength. Proximal muscles remained weaker than distal muscles in the upper extremities. Children who qualified for inpatient rehabilitation had ongoing respiratory needs at follow-up; however, recovery of nutritional status and bowel/bladder were similar | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute flaccid myelitis (AFM) | |
| 650 | 4 | |a Mobility | |
| 650 | 4 | |a Neurogenic bladder | |
| 650 | 4 | |a Neurogenic bowel | |
| 650 | 4 | |a Pediatrics | |
| 650 | 4 | |a Rehabilitation outcomes | |
| 650 | 4 | |a Self-care | |
| 650 | 4 | |a WeeFIM | |
| 700 | 1 | |a Feldman, Keith |e verfasserin |4 aut | |
| 700 | 1 | |a Sinn, Clarice |e verfasserin |4 aut | |
| 700 | 1 | |a Javaid, Simra |e verfasserin |4 aut | |
| 700 | 1 | |a Jaffe, Ashlee |e verfasserin |4 aut | |
| 700 | 1 | |a Katz, Elana |e verfasserin |4 aut | |
| 700 | 1 | |a Lider, Joshua |e verfasserin |4 aut | |
| 700 | 1 | |a Green, Michael M |e verfasserin |4 aut | |
| 700 | 1 | |a Marcus, Lydia |e verfasserin |4 aut | |
| 700 | 1 | |a Swanson, Erin |e verfasserin |4 aut | |
| 700 | 1 | |a Gober, Joslyn |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Sruthi P |e verfasserin |4 aut | |
| 700 | 1 | |a Deike, Dawn |e verfasserin |4 aut | |
| 700 | 1 | |a Felman, Kristyn |e verfasserin |4 aut | |
| 700 | 1 | |a Sinha, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Dalal, Pritha |e verfasserin |4 aut | |
| 700 | 1 | |a Ewing, Emily |e verfasserin |4 aut | |
| 700 | 1 | |a Hiller, Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenberg, Nathan |e verfasserin |4 aut | |
| 700 | 1 | |a Mosher, Kathryn A |e verfasserin |4 aut | |
| 700 | 1 | |a Houtrow, Amy J |e verfasserin |4 aut | |
| 700 | 1 | |a McLaughlin, Matthew J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric neurology |d 1993 |g 145(2023) vom: 30. Aug., Seite 41-47 |w (DE-627)NLM012947210 |x 1873-5150 |7 nnns |
| 773 | 1 | 8 | |g volume:145 |g year:2023 |g day:30 |g month:08 |g pages:41-47 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.pediatrneurol.2023.04.027 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 145 |j 2023 |b 30 |c 08 |h 41-47 | ||