Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
As a result of the ban on bisphenol A (BPA), a hormone disruptor with developmental neurotoxicity, several BPA derivatives (BPs) have been widely used in industrial production. However, there are no effective methods for assessing the neurodevelopmental toxic effects of BPs. To address this, a Drosophila exposure model was established, and W1118 was reared in food containing these BPs. Results showed that each BPs displayed different semi-lethal doses ranging from 1.76 to 19.43 mM. Exposure to BPs delayed larval development and affected axonal growth, resulting in the abnormal crossing of the midline of axons in the β lobules of mushroom bodies, but the damage caused by BPE and BPF was relatively minor. BPC, BPAF, and BPAP have the most significant effects on locomotor behavior, whereas BPC exhibited the most affected social interactions. Furthermore, exposure to high-dose BPA, BPC, BPS, BPAF, and BPAP also significantly increased the expression of Drosophila estrogen-related receptors. These demonstrated that different kinds of BPs had different levels of neurodevelopmental toxicity, and the severity was BPZ > BPC and BPAF > BPB > BPS > BPAP ≈ BPAl ≈ BPF > BPE. Therefore, BPZ, BPC, BPS, BPAF, and BPAP should be evaluated as potential alternatives to BPA.
| Errataetall: |
ErratumIn: Ecotoxicol Environ Saf. 2023 Jun 7;261:115118. - PMID 37295305 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:260 |
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| Enthalten in: |
Ecotoxicology and environmental safety - 260(2023) vom: 15. Juli, Seite 115098 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Jie [VerfasserIn] |
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| Links: |
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| Themen: |
Benzhydryl Compounds |
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| Anmerkungen: |
Date Completed 14.06.2023 Date Revised 16.06.2023 published: Print-Electronic ErratumIn: Ecotoxicol Environ Saf. 2023 Jun 7;261:115118. - PMID 37295305 Citation Status MEDLINE |
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| doi: |
10.1016/j.ecoenv.2023.115098 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a As a result of the ban on bisphenol A (BPA), a hormone disruptor with developmental neurotoxicity, several BPA derivatives (BPs) have been widely used in industrial production. However, there are no effective methods for assessing the neurodevelopmental toxic effects of BPs. To address this, a Drosophila exposure model was established, and W1118 was reared in food containing these BPs. Results showed that each BPs displayed different semi-lethal doses ranging from 1.76 to 19.43 mM. Exposure to BPs delayed larval development and affected axonal growth, resulting in the abnormal crossing of the midline of axons in the β lobules of mushroom bodies, but the damage caused by BPE and BPF was relatively minor. BPC, BPAF, and BPAP have the most significant effects on locomotor behavior, whereas BPC exhibited the most affected social interactions. Furthermore, exposure to high-dose BPA, BPC, BPS, BPAF, and BPAP also significantly increased the expression of Drosophila estrogen-related receptors. These demonstrated that different kinds of BPs had different levels of neurodevelopmental toxicity, and the severity was BPZ > BPC and BPAF > BPB > BPS > BPAP ≈ BPAl ≈ BPF > BPE. Therefore, BPZ, BPC, BPS, BPAF, and BPAP should be evaluated as potential alternatives to BPA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bisphenol A | |
| 650 | 4 | |a Bisphenols derivatives | |
| 650 | 4 | |a Drosophila | |
| 650 | 4 | |a Neurobehaviors | |
| 650 | 4 | |a Neurotoxicity | |
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| 650 | 7 | |a Benzhydryl Compounds |2 NLM | |
| 650 | 7 | |a Phenols |2 NLM | |
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| 700 | 1 | |a Zhang, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yuanyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Binquan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Mingkuan |e verfasserin |4 aut | |
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