18F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis : Results of a retrospective study at a tertiary center
© 2023. The Author(s)..
BACKGROUND: Abnormal activity of 18F-FDG PET/CT is a major Duke criterion in the diagnostic work-up of infective prosthetic valve endocarditis (IE). We hypothesized that quantitative lesion assessment by 18F-FDG PET/CT-derived standard maximum uptake ratio (SURmax), metabolic volume (MV), and total lesion glycolysis (TLG) might be useful in distinct subgroups of IE patients (e.g. IE-related abscess formation).
METHODS: All patients (n = 27) hospitalized in our tertiary IE referral medical center from January 2014 to October 2018 with preoperatively performed 18F-FDG PET/CT and surgically confirmed IE were included into this retrospective analysis.
RESULTS: Patients with surgically confirmed abscess formation (n = 10) had significantly increased MV (by ~ fivefold) and TLG (by ~ sevenfold) as compared to patients without abscess (n = 17). Receiver operation characteristics (ROC) analyses demonstrated that TLG (calculated as MV × SURmean, i.e. TLG (SUR)) had the most favorable area under the ROC curve (0.841 [CI 0.659 to 1.000]) in predicting IE-related abscess formation. This resulted in a sensitivity of 80% and a specificity of 88% at a cut-off value of 14.14 mL for TLG (SUR).
CONCLUSION: We suggest that 18F-FDG PET/CT-derived quantitative assessment of TLG (SUR) may provide a novel diagnostic tool in predicting endocarditis-associated abscess formation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 30(2023), 6 vom: 01. Dez., Seite 2400-2414 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sag, Sabine Julia Maria [VerfasserIn] |
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| Links: |
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| Themen: |
0Z5B2CJX4D |
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| Anmerkungen: |
Date Completed 28.11.2023 Date Revised 13.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s12350-023-03285-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357662938 |
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| 100 | 1 | |a Sag, Sabine Julia Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a 18F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis |b Results of a retrospective study at a tertiary center |
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| 500 | |a Date Revised 13.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Abnormal activity of 18F-FDG PET/CT is a major Duke criterion in the diagnostic work-up of infective prosthetic valve endocarditis (IE). We hypothesized that quantitative lesion assessment by 18F-FDG PET/CT-derived standard maximum uptake ratio (SURmax), metabolic volume (MV), and total lesion glycolysis (TLG) might be useful in distinct subgroups of IE patients (e.g. IE-related abscess formation) | ||
| 520 | |a METHODS: All patients (n = 27) hospitalized in our tertiary IE referral medical center from January 2014 to October 2018 with preoperatively performed 18F-FDG PET/CT and surgically confirmed IE were included into this retrospective analysis | ||
| 520 | |a RESULTS: Patients with surgically confirmed abscess formation (n = 10) had significantly increased MV (by ~ fivefold) and TLG (by ~ sevenfold) as compared to patients without abscess (n = 17). Receiver operation characteristics (ROC) analyses demonstrated that TLG (calculated as MV × SURmean, i.e. TLG (SUR)) had the most favorable area under the ROC curve (0.841 [CI 0.659 to 1.000]) in predicting IE-related abscess formation. This resulted in a sensitivity of 80% and a specificity of 88% at a cut-off value of 14.14 mL for TLG (SUR) | ||
| 520 | |a CONCLUSION: We suggest that 18F-FDG PET/CT-derived quantitative assessment of TLG (SUR) may provide a novel diagnostic tool in predicting endocarditis-associated abscess formation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 18F-FDG PET/CT | |
| 650 | 4 | |a infective endocarditis | |
| 650 | 4 | |a total lesion glycolysis | |
| 650 | 4 | |a valve abscess | |
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| 700 | 1 | |a Menhart, Karin |e verfasserin |4 aut | |
| 700 | 1 | |a Hitzenbichler, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Schmid, Christof |e verfasserin |4 aut | |
| 700 | 1 | |a Hofheinz, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a van den Hoff, Jörg |e verfasserin |4 aut | |
| 700 | 1 | |a Maier, Lars Siegfried |e verfasserin |4 aut | |
| 700 | 1 | |a Hellwig, Dirk |e verfasserin |4 aut | |
| 700 | 1 | |a Grosse, Jirka |e verfasserin |4 aut | |
| 700 | 1 | |a Sag, Can Martin |e verfasserin |4 aut | |
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