Synchrotron-based FTIR evaluation of biochemical changes in cancer and noncancer cells induced by brominated marine coelenteramine
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
The mode of action toward gastric cancer cells of brominated Coelenteramine, an analogue of a metabolic product of a marine bioluminescent reaction, was investigated by synchrotron radiation-based Fourier Transform Infrared spectrocopy (FTIR). This method revealed that the anticancer activity of brominated Coelenteramine is closely connected with cellular lipids, by affecting their organization and composition. More specifically, there is an increasing extent of oxidative stress, which results in changes in membrane polarity, lipid chain packing and lipid composition. However, this effect was not observed in a noncancer cell line, helping to explain its selectivity profile. Thus, synchrotron radiation-based FTIR helped to identify the potential of this Coelenteramine analogue in targeting membrane lipids, while proving to be a powerful technique to probe the mechanism of anticancer drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:743 |
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| Enthalten in: |
Archives of biochemistry and biophysics - 743(2023) vom: 15. Juli, Seite 109660 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Magalhaes, Carla M [VerfasserIn] |
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| Links: |
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| Themen: |
Anticancer therapy |
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| Anmerkungen: |
Date Completed 07.07.2023 Date Revised 18.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.abb.2023.109660 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357655443 |
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| 500 | |a Date Revised 18.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The mode of action toward gastric cancer cells of brominated Coelenteramine, an analogue of a metabolic product of a marine bioluminescent reaction, was investigated by synchrotron radiation-based Fourier Transform Infrared spectrocopy (FTIR). This method revealed that the anticancer activity of brominated Coelenteramine is closely connected with cellular lipids, by affecting their organization and composition. More specifically, there is an increasing extent of oxidative stress, which results in changes in membrane polarity, lipid chain packing and lipid composition. However, this effect was not observed in a noncancer cell line, helping to explain its selectivity profile. Thus, synchrotron radiation-based FTIR helped to identify the potential of this Coelenteramine analogue in targeting membrane lipids, while proving to be a powerful technique to probe the mechanism of anticancer drugs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Anticancer therapy | |
| 650 | 4 | |a Bioluminescence | |
| 650 | 4 | |a Coelenteramine | |
| 650 | 4 | |a Coelenterazine | |
| 650 | 4 | |a FTIR | |
| 650 | 4 | |a Synchrotron radiation | |
| 650 | 7 | |a Lipids |2 NLM | |
| 700 | 1 | |a Dučić, Tanja |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Renato B |e verfasserin |4 aut | |
| 700 | 1 | |a González-Berdullas, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Borges, José E |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, David M |e verfasserin |4 aut | |
| 700 | 1 | |a Esteves da Silva, Joaquim C G |e verfasserin |4 aut | |
| 700 | 1 | |a Algarra, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto da Silva, Luís |e verfasserin |4 aut | |
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