Associations between physical activity and cardiorespiratory fitness with vascular health phenotypes in older adults : a cross-sectional study
Copyright © 2023 de Sousa, Silva, Freire, Souto, Câmara, Cabral, Macêdo, Costa and Oliveira..
Objective: We investigated the associations between physical activity (PA) and cardiorespiratory fitness (CRF) with vascular health phenotypes in community-dwelling older adults. Methods: This cross-sectional study included 82 participants (66.8 ± 5.2 years; 81% females). Moderate-to-vigorous physical activity (MVPA) was assessed using accelerometers, and CRF was measured using the distance covered in the 6-min walk test (6MWT). The vascular health markers were as follows: i) arterial function measured as aortic pulse wave velocity (aPWV) estimated using an automatic blood pressure device; and ii) arterial structure measured as the common carotid intima-media thickness (cIMT). Using a combination of normal cIMT and aPWV values, four groups of vascular health phenotypes were created: normal aPWV and cIMT, abnormal aPWV only, abnormal cIMT only, and abnormal aPWV and cIMT. Multiple linear regression was used to estimate the beta coefficients (β) and their respective 95% confidence intervals (95% CI) adjusting for BMI, and medication for diabetes, lipid, and hypertension, sex, age, and blood pressure. Results: Participants with abnormal aPWV and normal cIMT (β = -53.76; 95% CI = -97.73--9.78 m; p = 0.017), and participants with both abnormal aPWV and cIMT (β = -71.89; 95% CI = -125.46--18.31 m; p = 0.009) covered less distance in the 6MWT, although adjusting for age, sex and blood pressure decreased the strength of the association with only groups of abnormal aPWV and cIMT covering a lower 6MWT distance compared to participants with both normal aPWV and cIMT (β = -55.68 95% CI = -111.95-0.59; p = 0.052). No associations were observed between MVPA and the vascular health phenotypes. Conslusion: In summary, poor CRF, but not MVPA, is associated with the unhealthiest vascular health phenotype (abnormal aPWV/cIMT) in older adults.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in physiology - 14(2023) vom: 26., Seite 1096139 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Sousa, Maria Karolina Ferreira [VerfasserIn] |
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| Links: |
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| Themen: |
6-min walk test |
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| Anmerkungen: |
Date Revised 01.06.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fphys.2023.1096139 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357581989 |
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| 100 | 1 | |a de Sousa, Maria Karolina Ferreira |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Associations between physical activity and cardiorespiratory fitness with vascular health phenotypes in older adults |b a cross-sectional study |
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| 520 | |a Copyright © 2023 de Sousa, Silva, Freire, Souto, Câmara, Cabral, Macêdo, Costa and Oliveira. | ||
| 520 | |a Objective: We investigated the associations between physical activity (PA) and cardiorespiratory fitness (CRF) with vascular health phenotypes in community-dwelling older adults. Methods: This cross-sectional study included 82 participants (66.8 ± 5.2 years; 81% females). Moderate-to-vigorous physical activity (MVPA) was assessed using accelerometers, and CRF was measured using the distance covered in the 6-min walk test (6MWT). The vascular health markers were as follows: i) arterial function measured as aortic pulse wave velocity (aPWV) estimated using an automatic blood pressure device; and ii) arterial structure measured as the common carotid intima-media thickness (cIMT). Using a combination of normal cIMT and aPWV values, four groups of vascular health phenotypes were created: normal aPWV and cIMT, abnormal aPWV only, abnormal cIMT only, and abnormal aPWV and cIMT. Multiple linear regression was used to estimate the beta coefficients (β) and their respective 95% confidence intervals (95% CI) adjusting for BMI, and medication for diabetes, lipid, and hypertension, sex, age, and blood pressure. Results: Participants with abnormal aPWV and normal cIMT (β = -53.76; 95% CI = -97.73--9.78 m; p = 0.017), and participants with both abnormal aPWV and cIMT (β = -71.89; 95% CI = -125.46--18.31 m; p = 0.009) covered less distance in the 6MWT, although adjusting for age, sex and blood pressure decreased the strength of the association with only groups of abnormal aPWV and cIMT covering a lower 6MWT distance compared to participants with both normal aPWV and cIMT (β = -55.68 95% CI = -111.95-0.59; p = 0.052). No associations were observed between MVPA and the vascular health phenotypes. Conslusion: In summary, poor CRF, but not MVPA, is associated with the unhealthiest vascular health phenotype (abnormal aPWV/cIMT) in older adults | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 6-min walk test | |
| 650 | 4 | |a accelerometry | |
| 650 | 4 | |a cardiovascular diseases | |
| 650 | 4 | |a intima-media thickness | |
| 650 | 4 | |a pulse wave velocity | |
| 700 | 1 | |a Silva, Raíssa de Melo |e verfasserin |4 aut | |
| 700 | 1 | |a Freire, Yuri Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Souto, Gabriel Costa |e verfasserin |4 aut | |
| 700 | 1 | |a Câmara, Marcyo |e verfasserin |4 aut | |
| 700 | 1 | |a Cabral, Ludmila Lucena Pereira |e verfasserin |4 aut | |
| 700 | 1 | |a Macêdo, Geovani Araújo Dantas |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Eduardo Caldas |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Ricardo Santos |e verfasserin |4 aut | |
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