Lidocaine-loaded dissolving microneedle for safe local anesthesia on oral mucosa for dental procedure
BACKGROUND: Lidocaine has been widely used as a short-acting local anesthetic agent to reduce the pain caused by needle insertion. Dissolving microneedles (DMNs), which are minimally invasive, can effectively deliver drugs by overcoming the oral mucosal barrier and relieving patient discomfort.
METHODS: Lidocaine solution prepared by mixing lidocaine-HCl and hyaluronic acid was used to fabricate oral lidocaine HCl-encapsulated DMNs (oral Li-DMNs) via centrifugal lithography. The dissolution, penetration ability, and local transmucosal drug delivery of oral Li-DMNs into the oral mucosa were evaluated in porcine jaws. Pharmacokinetic analysis and safety assessment were performed using rabbits.
RESULTS: The insertion depth of the oral Li-DMNs satisfies the safety standard. The oral Li-DMNs were completely dissolved after 3 min of application. The local transmucosal drug delivery, pharmacokinetic, and safety evaluations showed that the oral Li-DMNs can obtain a local anesthesia effect at a relatively lower dose, and there was no oral mucosal irritation in rabbits.
CONCLUSIONS: A novel and safe oral Li-DMNs have potential applications in large animals and clinical trials and would possibly enter the anesthesia market.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Expert opinion on drug delivery - 20(2023), 6 vom: 29. Juni, Seite 851-861 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Hyunkyu [VerfasserIn] |
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| Links: |
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| Themen: |
98PI200987 |
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| Anmerkungen: |
Date Completed 23.06.2023 Date Revised 25.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/17425247.2023.2216450 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357513134 |
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| 245 | 1 | 0 | |a Lidocaine-loaded dissolving microneedle for safe local anesthesia on oral mucosa for dental procedure |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Lidocaine has been widely used as a short-acting local anesthetic agent to reduce the pain caused by needle insertion. Dissolving microneedles (DMNs), which are minimally invasive, can effectively deliver drugs by overcoming the oral mucosal barrier and relieving patient discomfort | ||
| 520 | |a METHODS: Lidocaine solution prepared by mixing lidocaine-HCl and hyaluronic acid was used to fabricate oral lidocaine HCl-encapsulated DMNs (oral Li-DMNs) via centrifugal lithography. The dissolution, penetration ability, and local transmucosal drug delivery of oral Li-DMNs into the oral mucosa were evaluated in porcine jaws. Pharmacokinetic analysis and safety assessment were performed using rabbits | ||
| 520 | |a RESULTS: The insertion depth of the oral Li-DMNs satisfies the safety standard. The oral Li-DMNs were completely dissolved after 3 min of application. The local transmucosal drug delivery, pharmacokinetic, and safety evaluations showed that the oral Li-DMNs can obtain a local anesthesia effect at a relatively lower dose, and there was no oral mucosal irritation in rabbits | ||
| 520 | |a CONCLUSIONS: A novel and safe oral Li-DMNs have potential applications in large animals and clinical trials and would possibly enter the anesthesia market | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Dissolving microneedle | |
| 650 | 4 | |a Lidocaine | |
| 650 | 4 | |a Local anesthesia | |
| 650 | 4 | |a Pharmacokinetic analysis | |
| 650 | 4 | |a Transmucosal drug delivery | |
| 650 | 7 | |a Lidocaine |2 NLM | |
| 650 | 7 | |a 98PI200987 |2 NLM | |
| 700 | 1 | |a Min, Hye Su |e verfasserin |4 aut | |
| 700 | 1 | |a Jang, Mingyu |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Geonwoo |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Seongdae |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Chisong |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Young Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Ui-Won |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Somin |e verfasserin |4 aut | |
| 700 | 1 | |a Ryu, Hyeon Yeol |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Huisuk |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Hyungil |e verfasserin |4 aut | |
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