Neurophysiological correlates of altered time awareness in Alzheimer's disease and frontotemporal dementia
© 2023. Fondazione Società Italiana di Neurologia..
BACKGROUND: Alterations in time awareness have been reported in dementia, particularly in Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, the neurophysiological correlates underlying these alterations remain largely unexplored. This study aimed to investigate the neurophysiological correlates of altered time awareness in AD and FTD patients.
METHODS: A total of 150 participants (50 AD patients, 50 FTD patients, and 50 healthy controls [HC]) underwent a standardized neuropsychological assessment, an altered time awareness survey, and transcranial magnetic stimulation (TMS) to assess cholinergic (short latency afferent inhibition-SAI), GABAergic (short interval intracortical inhibition-SICI), and glutamatergic (intracortical facilitation-ICF) circuits.
RESULTS: In AD patients, the most frequent symptom was difficulty in ordering past events (52.0%), while FTD patients primarily struggled with estimating temporal intervals between events (40.0%). Significant differences were observed between HC and both patient groups, as well as between AD and FTD patients in their tendency to re-live past events. Binomial logistic regression analysis revealed that impairments in glutamatergic and cholinergic circuits significantly predicted the likelihood of participants manifesting altered time awareness symptoms.
CONCLUSIONS: This study provides novel insights into the neurophysiological correlates of altered time awareness in AD and FTD patients, highlighting the involvement of specific neurotransmitter circuits, particularly glutamatergic and cholinergic circuits. Further research is needed to explore the potential clinical implications and therapeutic targets arising from these findings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 44(2023), 10 vom: 29. Okt., Seite 3515-3522 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bracca, Valeria [VerfasserIn] |
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| Links: |
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| Themen: |
Acetylcholine |
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| Anmerkungen: |
Date Completed 12.09.2023 Date Revised 22.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10072-023-06877-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357492315 |
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| 245 | 1 | 0 | |a Neurophysiological correlates of altered time awareness in Alzheimer's disease and frontotemporal dementia |
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| 500 | |a Date Revised 22.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. Fondazione Società Italiana di Neurologia. | ||
| 520 | |a BACKGROUND: Alterations in time awareness have been reported in dementia, particularly in Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, the neurophysiological correlates underlying these alterations remain largely unexplored. This study aimed to investigate the neurophysiological correlates of altered time awareness in AD and FTD patients | ||
| 520 | |a METHODS: A total of 150 participants (50 AD patients, 50 FTD patients, and 50 healthy controls [HC]) underwent a standardized neuropsychological assessment, an altered time awareness survey, and transcranial magnetic stimulation (TMS) to assess cholinergic (short latency afferent inhibition-SAI), GABAergic (short interval intracortical inhibition-SICI), and glutamatergic (intracortical facilitation-ICF) circuits | ||
| 520 | |a RESULTS: In AD patients, the most frequent symptom was difficulty in ordering past events (52.0%), while FTD patients primarily struggled with estimating temporal intervals between events (40.0%). Significant differences were observed between HC and both patient groups, as well as between AD and FTD patients in their tendency to re-live past events. Binomial logistic regression analysis revealed that impairments in glutamatergic and cholinergic circuits significantly predicted the likelihood of participants manifesting altered time awareness symptoms | ||
| 520 | |a CONCLUSIONS: This study provides novel insights into the neurophysiological correlates of altered time awareness in AD and FTD patients, highlighting the involvement of specific neurotransmitter circuits, particularly glutamatergic and cholinergic circuits. Further research is needed to explore the potential clinical implications and therapeutic targets arising from these findings | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acetylcholine | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a Frontotemporal dementia | |
| 650 | 4 | |a GABA | |
| 650 | 4 | |a Glutamate | |
| 650 | 4 | |a Time-awareness | |
| 650 | 4 | |a Transcranial magnetic stimulation | |
| 650 | 7 | |a Cholinergic Agents |2 NLM | |
| 700 | 1 | |a Cantoni, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Gadola, Yasmine |e verfasserin |4 aut | |
| 700 | 1 | |a Rivolta, Jasmine |e verfasserin |4 aut | |
| 700 | 1 | |a Cosseddu, Maura |e verfasserin |4 aut | |
| 700 | 1 | |a Turrone, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a Caratozzolo, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Di Luca, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Borroni, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Benussi, Alberto |e verfasserin |4 aut | |
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