Evaluation of a Rabbit Model of Vascular Stent Healing : Application of Optical Coherence Tomography
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
Percutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). Despite advancements, in-stent restenosis (ISR) still imparts a 1-2% annual rate of repeat revascularization-a focus of ongoing translational research. Optical coherence tomography (OCT) provides high resolution virtual histology of stents. Our study evaluates the use of OCT for virtual histological assessment of stent healing in a rabbit aorta model, enabling complete assessment of intraluminal healing throughout the stent. ISR varies based on intra-stent location, stent length, and stent type in a rabbit model-important considerations for translational experimental design. Atherosclerosis leads to more prominent ISR proliferation independent of stent-related factors. The rabbit stent model mirrors clinical observations, while OCT-based virtual histology demonstrates utility for pre-clinical stent assessment. Pre-clinical models should incorporate clinical and stent factors as feasible to maximize translation to clinical practice.
| Errataetall: |
ErratumIn: J Cardiovasc Transl Res. 2023 Jul 5;:. - PMID 37407867 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
|---|---|
| Enthalten in: |
Journal of cardiovascular translational research - 16(2023), 5 vom: 25. Okt., Seite 1194-1204 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Simard, Trevor [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
In-stent restenosis (ISR) |
|---|
| Anmerkungen: |
Date Completed 01.11.2023 Date Revised 15.12.2023 published: Print-Electronic ErratumIn: J Cardiovasc Transl Res. 2023 Jul 5;:. - PMID 37407867 Citation Status MEDLINE |
|---|
| doi: |
10.1007/s12265-023-10399-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM357300696 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM357300696 | ||
| 003 | DE-627 | ||
| 005 | 20231227131259.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12265-023-10399-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1225.xml |
| 035 | |a (DE-627)NLM357300696 | ||
| 035 | |a (NLM)37227686 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Simard, Trevor |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of a Rabbit Model of Vascular Stent Healing |b Application of Optical Coherence Tomography |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.11.2023 | ||
| 500 | |a Date Revised 15.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: J Cardiovasc Transl Res. 2023 Jul 5;:. - PMID 37407867 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
| 520 | |a Percutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). Despite advancements, in-stent restenosis (ISR) still imparts a 1-2% annual rate of repeat revascularization-a focus of ongoing translational research. Optical coherence tomography (OCT) provides high resolution virtual histology of stents. Our study evaluates the use of OCT for virtual histological assessment of stent healing in a rabbit aorta model, enabling complete assessment of intraluminal healing throughout the stent. ISR varies based on intra-stent location, stent length, and stent type in a rabbit model-important considerations for translational experimental design. Atherosclerosis leads to more prominent ISR proliferation independent of stent-related factors. The rabbit stent model mirrors clinical observations, while OCT-based virtual histology demonstrates utility for pre-clinical stent assessment. Pre-clinical models should incorporate clinical and stent factors as feasible to maximize translation to clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a In-stent restenosis (ISR) | |
| 650 | 4 | |a Neointima | |
| 650 | 4 | |a Optical coherence tomography (OCT) | |
| 650 | 4 | |a Percutaneous coronary intervention (PCI) | |
| 650 | 4 | |a Rabbit | |
| 650 | 4 | |a Stent | |
| 650 | 4 | |a Translational | |
| 700 | 1 | |a Jung, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Di Santo, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Sarathy, Kiran |e verfasserin |4 aut | |
| 700 | 1 | |a Majeed, Kamran |e verfasserin |4 aut | |
| 700 | 1 | |a Motazedian, Pouya |e verfasserin |4 aut | |
| 700 | 1 | |a Short, Spencer |e verfasserin |4 aut | |
| 700 | 1 | |a Dhaliwal, Shan |e verfasserin |4 aut | |
| 700 | 1 | |a Labinaz, Alisha |e verfasserin |4 aut | |
| 700 | 1 | |a Sarma, Dhruv |e verfasserin |4 aut | |
| 700 | 1 | |a Ramirez, F Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Froeschl, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Labinaz, Marino |e verfasserin |4 aut | |
| 700 | 1 | |a Holmes, David R |e verfasserin |4 aut | |
| 700 | 1 | |a Alkhouli, Mohamad |e verfasserin |4 aut | |
| 700 | 1 | |a Hibbert, Benjamin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cardiovascular translational research |d 2008 |g 16(2023), 5 vom: 25. Okt., Seite 1194-1204 |w (DE-627)NLM18709375X |x 1937-5395 |7 nnns |
| 773 | 1 | 8 | |g volume:16 |g year:2023 |g number:5 |g day:25 |g month:10 |g pages:1194-1204 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12265-023-10399-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 16 |j 2023 |e 5 |b 25 |c 10 |h 1194-1204 | ||