Heart involvement in multisystem inflammatory syndrome in children correlated with SARS-CoV-2 infection : a review by ANMCO/SICP
Acute clinical manifestations of COVID-19 are generally less severe in childhood, however a proportion of them can develop a severe systemic hyperinflammatory syndrome after SARS-CoV-2 infection, known as the multisystem inflammatory syndrome (multisystem inflammatory syndrome in children, MIS-C). Cardiovascular manifestations in MIS-C are frequent (34-82%), including myocardial dysfunction, coronary artery dilation or aneurysms, arrhythmias, conduction abnormalities, pericarditis and valvulitis. The most affected cases can develop cardiogenic shock needing intensive care unit admission, inotropic support and sometimes even mechanical circulatory support. The elevation of myocardial necrosis markers, the frequently transient left ventricular systolic dysfunction and the presence of changes on magnetic resonance imaging, support the hypothesis of an immune-mediated post-viral pathogenesis similar to myocarditis. Although MIS-C shows excellent short-term survival, further studies are needed to demonstrate complete reversibility of residual subclinical heart damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Giornale italiano di cardiologia (2006) - 24(2023), 6 vom: 01. Juni, Seite 413-422 |
| Sprache: |
Italienisch |
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| Weiterer Titel: |
Le manifestazioni cardiache nella sindrome multisistemica infiammatoria del bambino correlate all’infezione da SARS-CoV-2: una rassegna a cura di ANMCO/SICP |
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| Beteiligte Personen: |
Sirico, Domenico [VerfasserIn] |
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| Anmerkungen: |
Date Completed 29.05.2023 Date Revised 29.05.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1714/4041.40199 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM357295765 |
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| 245 | 1 | 0 | |a Heart involvement in multisystem inflammatory syndrome in children correlated with SARS-CoV-2 infection |b a review by ANMCO/SICP |
| 246 | 3 | 3 | |a Le manifestazioni cardiache nella sindrome multisistemica infiammatoria del bambino correlate all’infezione da SARS-CoV-2: una rassegna a cura di ANMCO/SICP |
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| 520 | |a Acute clinical manifestations of COVID-19 are generally less severe in childhood, however a proportion of them can develop a severe systemic hyperinflammatory syndrome after SARS-CoV-2 infection, known as the multisystem inflammatory syndrome (multisystem inflammatory syndrome in children, MIS-C). Cardiovascular manifestations in MIS-C are frequent (34-82%), including myocardial dysfunction, coronary artery dilation or aneurysms, arrhythmias, conduction abnormalities, pericarditis and valvulitis. The most affected cases can develop cardiogenic shock needing intensive care unit admission, inotropic support and sometimes even mechanical circulatory support. The elevation of myocardial necrosis markers, the frequently transient left ventricular systolic dysfunction and the presence of changes on magnetic resonance imaging, support the hypothesis of an immune-mediated post-viral pathogenesis similar to myocarditis. Although MIS-C shows excellent short-term survival, further studies are needed to demonstrate complete reversibility of residual subclinical heart damage | ||
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| 700 | 1 | |a Russo, Maria Giovanna |e verfasserin |4 aut | |
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