Pre-existing sleep problems as a predictor of post-acute sequelae of COVID-19
© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society..
Several months after COVID-19 many individuals still report persisting symptoms, the so-called 'post-COVID-19 syndrome'. An immunological dysfunction is one of the main pathophysiological hypotheses. As sleep is central to the functioning of the immune system, we investigated whether self-reported pre-existing sleep disturbance might be an independent risk factor for the development of post-COVID-19 syndrome. A total of 11,710 participants of a cross-sectional survey (all tested positive for severe acute respiratory syndrome coronavirus-2) were classified into probable post-COVID-19 syndrome, an intermediate group, and unaffected participants at an average of 8.5 months after infection. The case definition was based on newly occurring symptoms of at least moderate severity and ≥20% reduction in health status and/or working capacity. Unadjusted and adjusted odds ratios were calculated to investigate the association between pre-existing sleep disturbances and subsequent development of post-COVID-19 syndrome while controlling for a variety of demographic, lifestyle, and health factors. Pre-existing sleep disturbances were found to be an independent predictor of subsequent probable post-COVID-19 syndrome (adjusted odds ratio 2.7, 95% confidence interval 2.27-3.24). Sleep disturbances as part of the post-COVID-19 syndrome were reported by more than half of the participants and appeared to be a new symptom and to occur independent of a mood disorder in most cases. Recognition of disturbed sleep as an important risk factor for post-COVID-19 syndrome should promote improved clinical management of sleep disorders in the context of COVID-19. Further, it may stimulate further research on the effect of improving sleep on the prognosis of COVID-19 long-term sequelae and other post-viral conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Journal of sleep research - 33(2024), 2 vom: 14. März, Seite e13949 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schilling, Claudia [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 18.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/jsr.13949 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM357293762 |
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| 520 | |a © 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. | ||
| 520 | |a Several months after COVID-19 many individuals still report persisting symptoms, the so-called 'post-COVID-19 syndrome'. An immunological dysfunction is one of the main pathophysiological hypotheses. As sleep is central to the functioning of the immune system, we investigated whether self-reported pre-existing sleep disturbance might be an independent risk factor for the development of post-COVID-19 syndrome. A total of 11,710 participants of a cross-sectional survey (all tested positive for severe acute respiratory syndrome coronavirus-2) were classified into probable post-COVID-19 syndrome, an intermediate group, and unaffected participants at an average of 8.5 months after infection. The case definition was based on newly occurring symptoms of at least moderate severity and ≥20% reduction in health status and/or working capacity. Unadjusted and adjusted odds ratios were calculated to investigate the association between pre-existing sleep disturbances and subsequent development of post-COVID-19 syndrome while controlling for a variety of demographic, lifestyle, and health factors. Pre-existing sleep disturbances were found to be an independent predictor of subsequent probable post-COVID-19 syndrome (adjusted odds ratio 2.7, 95% confidence interval 2.27-3.24). Sleep disturbances as part of the post-COVID-19 syndrome were reported by more than half of the participants and appeared to be a new symptom and to occur independent of a mood disorder in most cases. Recognition of disturbed sleep as an important risk factor for post-COVID-19 syndrome should promote improved clinical management of sleep disorders in the context of COVID-19. Further, it may stimulate further research on the effect of improving sleep on the prognosis of COVID-19 long-term sequelae and other post-viral conditions | ||
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| 700 | 1 | |a Nieters, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Schredl, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Peter, Raphael S |e verfasserin |4 aut | |
| 700 | 1 | |a Rothenbacher, Dietrich |e verfasserin |4 aut | |
| 700 | 1 | |a Brockmann, Stefan O |e verfasserin |4 aut | |
| 700 | 1 | |a Göpel, Siri |e verfasserin |4 aut | |
| 700 | 1 | |a Kindle, Gerhard |e verfasserin |4 aut | |
| 700 | 1 | |a Merle, Uta |e verfasserin |4 aut | |
| 700 | 1 | |a Steinacker, Jürgen M |e verfasserin |4 aut | |
| 700 | 1 | |a Kern, Winfried |e verfasserin |4 aut | |
| 700 | 0 | |a Epidemiology of Long COVID (EPILOC) Phase I study group |e verfasserin |4 aut | |
| 700 | 1 | |a August, Dietrich |e investigator |4 oth | |
| 700 | 1 | |a Bauer, Christoph |e investigator |4 oth | |
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| 700 | 1 | |a Deibert, Peter |e investigator |4 oth | |
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| 700 | 1 | |a Giesen, Roland |e investigator |4 oth | |
| 700 | 1 | |a Götz, Veronika |e investigator |4 oth | |
| 700 | 1 | |a Grote, Sylvia |e investigator |4 oth | |
| 700 | 1 | |a Grüner, Beate |e investigator |4 oth | |
| 700 | 1 | |a Junginger, Alexandra |e investigator |4 oth | |
| 700 | 1 | |a Kappert, Oliver |e investigator |4 oth | |
| 700 | 1 | |a Kirsten, Johannes |e investigator |4 oth | |
| 700 | 1 | |a Kräusslich, Hans-Georg |e investigator |4 oth | |
| 700 | 1 | |a Kühn, Anne |e investigator |4 oth | |
| 700 | 1 | |a Malek, Nisar P |e investigator |4 oth | |
| 700 | 1 | |a Müller, Barbara |e investigator |4 oth | |
| 700 | 1 | |a Niess, Andreas |e investigator |4 oth | |
| 700 | 1 | |a Pfau, Stefanie |e investigator |4 oth | |
| 700 | 1 | |a Piechotowski, Isolde |e investigator |4 oth | |
| 700 | 1 | |a Rieg, Siegbert |e investigator |4 oth | |
| 700 | 1 | |a Röttele, Sibylle |e investigator |4 oth | |
| 700 | 1 | |a Schellenberg, Jana |e investigator |4 oth | |
| 700 | 1 | |a Schröder, Chantal |e investigator |4 oth | |
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| 700 | 1 | |a Spannenkrebs, Monika |e investigator |4 oth | |
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| 700 | 1 | |a Wolfers, Kersten |e investigator |4 oth | |
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